Department of Biomedical Engineering
Eindhoven University of Technology
P.O. Box 513
5600 MB  EINDHOVEN
The Netherlands

Office: HG  -1.26
Telephone: +31 40 247 5349
E-mail: p.englebienne@remove-this.tue.nl


Biography
Pablo Englebienne was born in Buenos Aires, Argentina, in 1978. He completed his undergraduate degree at the University of Buenos Aires, receiving his licenciatura degree in Chemistry in 2002, focusing on organic chemistry and microbiology. After working for a year as a synthetic organic chemist for a pharmochemical company in Argentina, he joined the group of Nicolas Motessier in the Chemistry department at McGill University in Montreal, Canada, where he obtained his Ph.D. degree in 2009. His doctoral work dealt with the development and application of computational methods for drug design. He was part of the development team of a suite of programs for molecular docking and its application to virtual screening, Forecaster. He received the CCG Excellence Award from the American Chemical Society in the 2007 Spring National Conference in New Orleans. In 2009, he joined the ICMS as postdoctoral fellow, in a joint project between the groups of Bert Meijer in Chemical Engineering and Peter Hilbers at Biomedical Engineering. His current research focuses on the simulation of synthetic polymers containing groups capable of supramolecular self-assembling leading to the formation of single-chain polymer nanoparticles.

 Publications

• Kieltyka, R.; Englebienne, P.; Moitessier, N.; Sleiman, H. F. Quantifying interactions between G-quadruplex DNA and transition metal complexes. Meth. Mol. Biol., 2010, 608, 223.
• Englebienne, P.; Moitessier, N. Docking Ligands into Flexible and Solvated Macromolecules. 5. Force-field-based prediction of binding affinities of ligands to proteins. J. Chem. Inf. Model., 2009, 49, 2564.
• Englebienne, P.; Moitessier, N. Docking Ligands into Flexible and Solvated Macromolecules. 4. Are Popular Scoring Functions Accurate for this Class of Proteins? J. Chem. Inf. Model., 2009, 49, 1568.
• Kieltyka, R.; Englebienne, P.; Fakhoury, J.; Autexier, C.; Moitessier, N.; Sleiman, H. F. A platinum supramolecular square structure as a G-quadruplex interactive agent. J. Am. Chem. Soc. 2008, 130, 10040.
• Corbeil, C. R.; Englebienne, P.; Yannopoulos, C. G.; Chan, L.; Das, S. K.; Bilimoria, D.; L\'Heureux, L.; Moitessier, N. Docking Ligands into Flexible and Solvated Macromolecules. 2. Development and Application of Fitted 1.5 to the Virtual Screening of Potential HCV Polymerase Inhibitors. J. Chem. Inf. Model. 2008, 48, 902.
• Moitessier, N.; Englebienne, P.; Lee, D.; Lawandi, J.; Corbeil, C. R., Towards the development of universal, fast and highly accurate docking/scoring methods: A long way to go. Br. J. Pharmacol. 2008, 153, S7.
• Englebienne, P.; Fiaux, H.; Kuntz, D. A.; Corbeil, C. R.; Gerber-Lemaire, S.; Rose, D. R.; Moitessier, N. Evaluation of Docking Programs for Predicting Binding of Golgi alpha-Mannosidase II Inhibitors: A Comparison with Crystallography. Proteins: Struct., Funct., Bioinf. 2007, 69, 160.
• Corbeil, C. R.; Englebienne, P.; Moitessier, N. Docking Ligands into Flexible and Solvated Macromolecules. 1. Development and Validation of Fitted 1.0. J. Chem. Inf. Model. 2007, 47, 43.
• Moitessier, N.; Englebienne, P.; Chapleur, Y. Directing-protecting groups for carbohydrates. Design, conformational study, synthesis and application to regioselective functionalization. Tetrahedron 2005, 61, 6839.
• Englebienne, P.; López, M. G.; Cortón, E.; Viale, A. A. Use of a CO2 electrode to monitor fermentations that use xenobiotic compounds as source of carbon. Rev. Arg. Microbiol. 2002, 34, 72.