TU Eindhoven Sensing Team (T.E.S.T.)

T.E.S.T. competes in the annual SensUs competition, striving to transform healthcare by developing innovative new biosensors.


  • You are enrolled in a BSc or MSc program at the TU/e.
  • You have passed your first year.
  • You can spend around 10 hours per week on this project.

The 2021 Team

 The challenge of SensUs 2021 was to develop a biosensor to detect the acute respiratory virus influenza A by a rapid saliva test.

Influenza viruses are known to mutate quickly, contributing to pandemic-type situations in society sooner rather than later. As the Covid-19 pandemic has shown, rapid testing of patients is crucial to contain the spread of viruses, and to avoid pandemic-type situations.

With hard work and dedication T.E.S.T. 2021 managed to win one of four awards during the SensUs competition: the Translational Potential Award.


The 2020 team

The challenge of SensUs 2020 is to develop a biosensor for the measurement of unbound Valproate. This is a biological drug that is prescribed to patients suffering from epilepsy. Epilepsy is a chronic noncommunicable disease of the brain that affects people of all ages. Around 50 million people worldwide have epilepsy, making it one of the most common neurological diseases globally. SensUs is a yearly international student competition on molecular biosensors for medical diagnostics and healthcare applications. Every participating team will make a biosensor for the measurement of unbound Valproate. 


This year’s team is focusing on SensUs’ latest challenge:

The development of a biosensor for the medicine Adalimumab, sold as Humira, a drug used to fight rheumatoid arthritis and other autoimmune diseases. Rheumatoid arthritis is a chronic inflammatory disorder that is characterized by inflammation of the synovium of small joints, like the hands and feet, which leads to the destruction of articular cartilage and bone. The cause of this disorder is not well understood, but the overexpression of proinflammatory cytokines plays an important role. One cytokine that plays a key role is TNF-alfa, Adalimumab binds specifically to this cytokine.

Blood measurements are currently being done sporadically and the dosage is adjusted to the severity of complaints a patient has. Furthermore, the costs of the medication are high, since Adalimumab is one of the three most expensive medicines in the Netherlands. More personalized care and reduction of costs are therefore needed.

Our biosensor uses bioluminescence where we capture Adalimumab with two antibodies that bring together a fluorescent protein. We are currently working hard to realize our assay and the first results seem promising. We have already measured the signal! Coming from absorbed photons from bioluminescence by the antibody coupling.

In addition, we are also working on a cartridge whose design is now complete and many tests are being carried out to dry the compartments in the front of the sensor. Finally, the detection team is busy selecting and testing lenses and photo diodes.

The SensUs competition will take place in September 2019 and everyone is welcome to visit.

We are currently competing in the TU/e Contest and are happy to announce that we current made it to the top 40!

We are working towards getting into the final. The announcement of the finalists is coming soon, so we're very excited!

We will keep you updated!

The 2018 team

The created biosensor detects the concentration of vancomycin, a last-ditch antibiotic used for bacterial strains that are already resistant to multiple other antibiotics. The biosensor for vancomycin can be used by patients to recover in the comfort of their home, drastically cutting the amount of blood and time necessary for measurement of vancomycin blood concentration, allowing for faster and more accurate medicine administration. Patients will no longer be required to give large amounts of blood; a small finger prick suffices.

The measurement principle made use of magnetic particles coated with vancomycin and anti-vancomycin antibodies to specifically form dimers. In the presence of free vancomycin in the patient’s blood plasma the vancomycin coated particles and the free vancomycin are in competition to bind to the antibodies resulting in a higher vancomycin concentration in the opto-magnetic readout.

During their project they took part in the annual TU/e Contest which they won as the most promising student team.



The second T.E.S.T. team developed a biosensor for NT-proBNP, a biomarker for heart failure, a disease afflicting 1% of all Europeans. Heart failure damages patients’ mobility and forces frequent hospital trips. T.E.S.T. contributed to the treatment of heart failure by adapting an opto-magnetic cluster assay developed by Adrea Ranzoni of Menno Prins’ Molecular Biosensing for Medical Diagnostics research group (TU/e): with this principle, they booked spectacular results, winning three of the four prizes of the SensUs event.

The 2016 team

The inaugural T.E.S.T. team was tasked with measuring creatinine, a biomarker for kidney failure. Kidney failure afflicts 70 million Europeans, chackling them to medication and dialysis machines. They received the creativity award for their elegant adaption of a principle developed by the Protein Engineering research group of Maarten Merkx (TU/e): a fluorescence (BRET-based) competition assay directly readable with a smartphone.

  • 24 Mar
    [Translate to English:]

    Inaugural lecture prof.dr. Michel Chaudron

    March 24, 2023 4:00 PM / Blauwe Zaal

  • 24 Mar
    28 Mar
    March 13, 2023
    Departmental Webinar series for TU/e Faculty and Staff

    JoVE in Teaching and Practical Training

    March 24, 2023 / Online

  • 24 Mar

    The Last of Us Lunch Lecture

    March 24, 2023 12:30 PM / de Filmzaal/Lounge of the Zwarte Doos

  • 24 Mar
    Membrane‐assisted direct dehydrogenation technology for light olefins production

    PhD defense Camilla Brencio

    March 24, 2023 / TU/e Campus

  • 24 Mar
    Unraveling the physics of the hygro-expansion of paper

    PhD defense Nicolaas Hendrikus Vonk

    March 24, 2023 / TU/e Campus

  • 27 Mar
    AI for the real world

    Women in Data Science Eindhoven 2023

    After a succesfull in-person event last year, Women in Data Science (WiDS) Eindhoven will return on Monday 27 March 2023.

  • 28 Mar
    Formalization, Analysis, and Sampled-Data Design of Hybrid Integrator-Gain Systems

    PhD defense Bardia Sharif

    March 28, 2023 / TU/e Campus

  • 28 Mar
    Neuron data
    Synapses and Silicon: Exploring the Intersection of AI and Neuroscience

    EAISI AI Symposium

    Symposium in honor of the opening of Neuron: Synapses and Silicon: exploring the intersection of AI and neuroscience.

  • 28 Mar

    Official Opening Neuron building

    The festive opening of the Neuron building is intended for all TU/e students, staff and invitees. This building will house lecture rooms and…

  • 29 Mar

    The bright side of life

    March 29, 2023 12:40 PM / Blauwe Zaal, Auditorium

  • 29 Mar
    Aspects of Synthesis, Structure and Catalytic Performance of Alumina Supported NiMo Hydrotreating Catalysts

    PhD defense Mengyan Li

    March 29, 2023 / TU/e Campus

  • 29 Mar
    Break the Code?

    PhD defense Lina Maria Ochoa Venegas

    March 29, 2023 / TU/e Campus

  • Contact us

    • Contact

    • Postal address

      PO Box 513
      5600MB Eindhoven
    • Visiting address

      TU/e Innovation Space, Matrix (Floor 1)
      Building number 10
      Groene Loper 10
      5612 AZ Eindhoven

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