8WC00 - Regeneration


The various tissues of the human body show an intriguing adaptive capacity. Their composition, structure, differentiation and function may change as a consequence of growth, adaptation to environmental cues, injury, or disease. The body knows several inherent strategies to cope with these changes, which can be used or mimicked for new clinical treatment modules like regenerative medicine.

The course is built on four pillars that treat:

  1. Growth, differentiation, and regeneration of specific tissues and during different stages of development
    • Foetal development, growth, maintenance of adult tissues and senescence.
    • Stem cells, proliferation, differentiation in various tissues and stages of development.
    • Maintenance and regeneration of various tissues (blood, skin, gut, muscle, bone, nerve)
  2. Damage, repair, adaptation and remodelling of tissue
    • Triggers for tissue damage and response to damage, reversible versus irreversible cell damage.
    • Inflammation and wound healing
    • Repair versus regeneration
  3. Pathological repair, adaptation and remodelling
    • Atherosclerosis, fibrosis, cancer
  4. Principles and application of regenerative medicine



Learning objectives

  • To understand and recognize the basic biological processes of growth, differentiation, maintenance and adaptation of human body tissues at the molecular, cellular and tissue level. To obtain insight into abnormal wound healing, repair and adaptation, e.g. under pathological conditions.
  • To apply the above processes for regenerative medicine approaches, where basic biology is combined with engineering and clinical sciences.


Responsible lecturer: C.V.C. (Carlijn) Bouten.

Co-lecturers: A. (Anita) Driessen - Mol, C.M. (Cecilia) Sahlgren.