Fast scale up using microreactors : From microscale to production
Conference ContributionNieuwland, P.J., Koch, K., Becker, R., Hest, van, J.C.M. & Rutjes, F.P.J.T. (2010). Fast scale up using microreactors : From microscale to production. 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 (pp. 995-997). In Scopus Cited 0 times.
In this study, the excellent scalability of flow chemistry was shown. Selective formation of mono-a-bromoketones was chosen as a model reaction. In a full multivariate optimization experiment, 60 different settings for reaction parameters such as temperature and reaction time were screened, requiring only small amounts of chemicals. A mathematical model of the data was obtained and an optimum set of reaction parameters was selected. These settings were applied on a larger scale continuous flow system and led to a production of the target compound phenacyl bromide at a 1.1 g/hr rate.