Hierarchical formation of supramolecular transient networks in water : a modular injectable delivery system
ArticleDankers, P.Y.W., Hermans, T.M., Baughman, T.W., Kamikawa, Y., Kieltyka, R.E., Bastings, M.M.C., Janssen, H.M., Sommerdijk, N.A.J.M., Larsen, A., Luyn, van, M.J.A., Bosman, A.W., Popa, E.R., Fytas, G. & Meijer, E.W. (2012). Hierarchical formation of supramolecular transient networks in water : a modular injectable delivery system. Advanced Materials, 24(20), 2703-2709. In Scopus Cited 114 times.
A modular one-component supramolecular transient network in water, based on poly(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution.