Palladium-catalyzed aerobic oxidative coupling of o-Xylene in flow : A Safe and Scalable Protocol for Cross-Dehydrogenative Coupling
ArticleErdmann, N., Su, Y., Bosmans, B.L., Hessel, V. & Noël, T. (2016). Palladium-catalyzed aerobic oxidative coupling of o-Xylene in flow : A Safe and Scalable Protocol for Cross-Dehydrogenative Coupling. Organic Process Research & Development, 20(4), 831-835. In Scopus Cited 6 times.
Herein, the first continuous cross-dehydrogenative homocoupling of an unactivated arene using oxygen as sole oxidant is reported. Employing microreactor technology which enables the use of elevated temperatures and pressures leads to a boost of the catalytic reaction. Hence, a major reduction in reaction time is achieved. Due to the significance as precursor for MOFs as well as high-tech and high-value polymers, the study focused on the production of 3,4,3′,4′-tetramethyl-biphenyl.