Aim in the track 'Imaging' is to develop clinical measurement techniques to assess the geometrical, biomechanical and morphological properties of primarily cardiovascular tissue (heart, arteries/veins), and in the musculoskeletal system, i.e., muscle, cartilage, and skin. The ultimate goal is to improve diagnosis, clinical decision making, and monitoring of disease progression over time, and/or guide therapy/intervention using a non-invasive imaging modality that is easily accessible, cost-effective and radiation-free.
Focus is on ultrasound imaging, which combines a high spatial and temporal resolution and enables functional imaging. New 3-D and 4-D ultrasound techniques are developed for improved imaging of these organs, but also for functional measurements of motion/flow, strain and biomechanical parameters. Moreover, molecular imaging is performed by means of non-invasive, spectroscopic photoacoustic imaging to differentiate between different tissues based on their optical absorption properties. Use of ultrasound under dynamic conditions has been developed for imaging during exercise in the fields of cardiology, musculoskeletal research, and sports medicine. A large area of research is patient-specific biomechanical modeling of organs using the aforementioned imaging data as input.
Techniques are validated experimentally and pre-clinically to assess its applicability and merit before being translated into the clinic. Many clinical collaborations are established for 'first in man' and/or feasibility studies, as well as clinical pilot studies and longitudinal studies in vivo.
Mechanical Characterization of Ascending Thoracic Aortic Aneurysms
ATAAs, aneurysms in the ascending thoracic aorta, are a life threatening condition.
Ultrasonic Characterization of Vulnerable Plaques
If plaque builds up in the body's arteries, the condition is called atherosclerosis.
Photoacoustic Characterization of Vulnerable Plaques
Photoacoustic imaging is a novel modality that allows non-invasive imaging of superficial arteries by combining high ultrasound resolution...
Peri-Operative Risk Assessment of Abdominal Aortic Aneurysms Using 4D and Multi-Perspective Ultrasound
To improve the risk assessment in patients with abdominal aortic aneurysms (AAAs), an ultrasound based method has been developed to estimate...
Dynamic Ultrasound Skeletal Muscles Analysis during Human Locomotion and Exercise
Measuring tissue perfusion is valuable for diagnosis and treatment monitoring in numerous diseases.
Non-Invasive Measurement of Cardiac Function Using Ultrasound Strain Imaging
Ultrasound is the most common imaging tool used when clinicians perform quantitative measurements of cardiac function.
Improved Cardiac Imaging with Multi-Perspective Ultrasound