The research topic 'Modelling' focusses on the development of patient-specific computational models of the cardiovascular system.
Cardiac models link cardiac function at tissue level and organ level and enable translation of information on cardiac function, observed in the clinic (e.g. pressures, deformations, heart rates), into information on the mechanical, electrical and metabolic state of the tissue. Special focus lies on modeling the long term change in cardiac properties in response to disease and treatment.
System level models are used in the field of perinatal and perioperative monitoring. They integrate cardiovascular function, neural and humoral regulation, pulmonary function and fluid exchange between the vascular and the interstitial space.
Vascular models can predict the development of vascular disease and outcome of clinical intervention.
Fluid-structure interaction models enable simulation of blood flow in specific arteries in order to obtain insight into the occurrence of vascular diseases.
Our computational models are also used to link measurements to risk factors that cannot be measured directly and predict outcome of intervention. In this way, the patient specific cardiovascular modeling aims at assisting in clinical decision support and intervention planning (e.g. angioplasty, valve replacement and vascular access surgery).
Vascular Access for Dialysis Patients
An irreversible loss in kidney function results in accumulation of fluid and metabolic waste products in the human body that finally leads...
Diagnosis and Intervention in Coronary Artery Disease
Coronary artery disease, in which the coronary arteries are partly or totally obstructed by atherosclerotic plaques (stenosis), is one of...
Diagnosis and Intervention in Peripheral Circulation Disease and Disorders
The study of flow in the peripheral circulation is important for the diagnosis and intervention in peripheral artery disease such as...
Flow and Autoregulation in Cerebral Arteries
Ischemic and hemorrhagic stroke occur 15-20 million times a year and form a major cause of maternal mortality and morbidity.
High-risk pregnancies are becoming more prevalent because of the progressively higher age at which women get pregnant.
During major surgery fluids are lost due to haemorrhage, perspiration and evaporation.
Cardiac dysfunction may have many causes, such as an infarction, an electrical conduction disorder, a valvular disease, cardiac...