supramolecular architecture and drug discovery
The Chemical Biology group is a research group within the department of Biomedical Engineering. The group is supervized by Prof.dr.ir. Luc Brunsveld.
In this group, research deals with chemical biology approaches to study protein-protein interactions. The two general lines that are being followed are supramolecular architecture and drug discovery.
Supramolecular chemistry deals with molecular architectures that are assembled by the reversible interaction of two or more chemical species...
Nuclear Receptor-Cofactor Interaction
Nuclear receptors (NRs) are multi-domain ligand-modulated transcription factors that act by targeting chromatin-modifying complexes and the...
14-3-3 Protein-Protein Interactions
In comparison to the size of the human proteome (~25,000), the estimated numbers of PPIs in the human interactome (650,000) is much larger...
Meet some of our Researchers
Iris Leijten - van de Gevel
Rens de Vries
The Chemical Biology group provides courses and projects in the bachelor's and master's program.
Furthermore, there are always sufficient projects for students to work on in the research group.
Our most recent peer reviewed publications
A CRISPR-Cas9 screen identifies essential CTCF anchor sites for estrogen receptor-driven breast cancer cell proliferationNucleic Acids Research (2019)
Emerging modes-of-action in drug discoveryMedChemComm (2019)
Optimized (pre)analytical conditions and workflow for droplet digital PCR analysis of cell-Free DNA from patients with suspected lung carcinomaThe Journal of Molecular Diagnostics (2019)
A multicenter evaluation of a point of care CRP TestClinical Biochemistry (2019)
Efficient small-scale conjugation of DNA to primary antibodies for multiplexed cellular targetingBioconjugate Chemistry (2019)