supramolecular architecture and drug discovery
The Chemical Biology group is a research group within the department of Biomedical Engineering. The group is supervized by Prof.dr.ir. Luc Brunsveld.
In this group, research deals with chemical biology approaches to study protein-protein interactions. The two general lines that are being followed are supramolecular architecture and drug discovery.
Supramolecular chemistry deals with molecular architectures that are assembled by the reversible interaction of two or more chemical species...
Nuclear Receptor-Cofactor Interaction
Nuclear receptors (NRs) are multi-domain ligand-modulated transcription factors that act by targeting chromatin-modifying complexes and the...
14-3-3 Protein-Protein Interactions
In comparison to the size of the human proteome (~25,000), the estimated numbers of PPIs in the human interactome (650,000) is much larger...
Meet some of our Researchers
Pim de Vink
Rens de Vries
Eline Sijbesma-Van Dun
The Chemical Biology group provides courses and projects in the bachelor's and master's program.
Furthermore, there are always sufficient projects for students to work on in the research group.
Our most recent peer reviewed publications
Prognostic Value of Combined Biomarkers in Patients With Heart FailureAnnals of Laboratory Medicine (2023)
Leveraging molecular structure and bioactivity with chemical language models for de novo drug designNature Communications (2023)
Up-front mutation detection in circulating tumor DNA by droplet digital PCR has added diagnostic value in lung cancerTranslational Oncology (2023)
Designing Selective Drug-like Molecular Glues for the Glucocorticoid Receptor/14-3-3 Protein-Protein InteractionJournal of Medicinal Chemistry (2022)
Exposing the Limitations of Molecular Machine Learning with Activity CliffsJournal of Chemical Information and Modeling (2022)