supramolecular architecture and drug discovery
The Chemical Biology group is a research group within the department of Biomedical Engineering. The group is supervized by Prof.dr.ir. Luc Brunsveld.
In this group, research deals with chemical biology approaches to study protein-protein interactions. The two general lines that are being followed are supramolecular architecture and drug discovery.
Supramolecular chemistry deals with molecular architectures that are assembled by the reversible interaction of two or more chemical species...
Nuclear Receptor-Cofactor Interaction
Nuclear receptors (NRs) are multi-domain ligand-modulated transcription factors that act by targeting chromatin-modifying complexes and the...
14-3-3 Protein-Protein Interactions
In comparison to the size of the human proteome (~25,000), the estimated numbers of PPIs in the human interactome (650,000) is much larger...
Meet some of our Researchers
Rens de Vries
Iris Leijten - van de Gevel
The Chemical Biology group provides courses and projects in the bachelor's and master's program.
Furthermore, there are always sufficient projects for students to work on in the research group.
Our most recent peer reviewed publications
Cell-free microcompartmentalised transcription–translation for the prototyping of synthetic communication networksCurrent Opinion in Biotechnology (2019)
Modulating protein–protein interaction networks in protein homeostasisCurrent Opinion in Chemical Biology (2019)
CHD1 loss alters AR binding at lineage-specific enhancers and modulates distinct transcriptional programs to drive prostate tumorigenesisCancer Cell (2019)
Arginine mimetic appended peptide-based probes for fluorescence turn-on detection of 14-3-3 proteinsOrganic and Biomolecular Chemistry (2019)
DNA-based communication in populations of synthetic protocellsNature Nanotechnology (2019)