Wafer scanners, electron microscopes, production printers and magnetic resonance imaging scanners are primary examples of high-tech cyber-physical systems. CPSe focusses on cross-disciplinary engineering methods and tools to efficiently develop next generations of systems with improved productivity, accuracy and flexibility at reduced costs. Engineering methods include model-based and platform-based design, design automation, virtual prototyping and digital twinning (for anomaly detection, root-cause analysis, what-if-analysis and optimization).