Departments of Applied Physics / Biomedical Engineering

Molecular Biosensing

The MBx group develops technologies based on micro- and nanoparticles for monitoring patients and for treating diseases. Towards this goal, the unique approach of MBx is to use advanced optical imaging techniques that quantify molecular processes with single molecule resolution within complex biomacromolecular environments.

Quantify molecular processes with single molecule resolution

The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.

Research Areas

Plasmonic Sensing

The Molecular Plasmonics group develops nanophotonic and plasmonic approaches for single-molecule detection using a single particle−single…

Research Area of Molecular Biosensing

Biosensing by Particle Motion

Research Area of Molecular Biosensing for Medical Diagnostics

Nanoscopy for Nanomedicine

The development of nanostructured materials to achieve innovation in healthcare, i.e. nanomedicine, is one of the great challenges in…

Former research areas

UPCOMING TECHNOLOGIES FOR CLINICAL IMMUNOLOGY

  • 12 Feb
    25 Jun

    CWTe Intellectual Property (IP) Research Challange

    February 12, 2025 2:00 PM - June 25, 2025 / To be finalized

  • 22 Apr
    ALT lunch session

    Inclusive classrooms in action: Fostering equity and collaboration in diverse classrooms

    Have you ever stepped into a classroom where one gender dominates the conversation? Or faced challenges in supervising a group project where…

  • 23 Apr
    Exhibition Entanglements

    PhD defense Michael Andrés Forero Parra

    April 23, 2025 / TU/e Campus

  • 23 Apr

    The Gate Academy | Masterclass

    April 23, 2025 3:30 PM / Room 2.12 - Alpha Hub, 2nd floor - Eeuwsel 57

  • 23 Apr
    Bridging Explainable AI and Visual Analytics for Deep Image-to-Image Models

    PhD defense Vidya Madapusi Srinivas Prasad

    April 23, 2025 / TU/e Campus

  • 23 Apr
    Co-Design Interaction for Offering Authentic Experiences in Airbnb

    PhD defense Jingrui An

    April 23, 2025 / TU/e Campus

  • 23 Apr
    human-centered AI
    Advancing Human-Centered AI

    Mini-Symposium: From Generative Imaging to Visual Analytics

    Organized on the occasion of Vidya Prasad’s PhD thesis defense.

  • 23 Apr
    April 11, 2025

    MST - ICMS Guest Lecture

    April 23, 2025 11:00 AM / Ceres 0.31

  • 23 Apr

    The Gender Script

    April 23, 2025 12:40 PM / Blauwe Zaal

  • 24 Apr
    kolibri grafitti EAISI

    EAISI lecture of visiting Professor Patrick Ebel

    A lecture about Design and the Social Construction of AI

  • 24 Apr

    Art, Science & Technology–an uneasy encounter

    April 24, 2025 12:40 PM / Blauwe Zaal

  • 25 Apr
    Chemical Recycling of Polycarbonates

    PhD defense Keita Saito

    April 25, 2025 / TU/e Campus

    • Work with us!

    Building a better future for our global society? Join our research team and be part of the thriving community at Eindhoven University of Technology.

    Working at the department of Biomedical Engineering or Applied Physics

    We are continuously looking for enthusiastic and motivated students and postdocs. If you would like to work in a great environment at TU/e, please contact one of the staff members for more information.

     

    Meet some of our Researchers

    Doctoral Candidate

    Chris Vu

    Associate Professor

    Lorenzo Albertazzi

    Full Professor

    Peter Zijlstra

    Project Manager

    Yuyang Wang

    Full Professor

    Menno Prins

    Postdoc

    Mrigank Singh Verma

    Doctoral Candidate

    Serena Calierno

    Doctoral Candidate-TA

    Marrit Tholen

    Associate Professor

    Leo van Ijzendoorn

    Assistant Professor

    Arthur de Jong

    Recent Publications

    Our most recent peer reviewed publications

    About the research group

    News

    April 10, 2025
    Going for gold: How gold nanoparticles can revolutionise biosensing
    Vincenzo Lamberti defended his PhD thesis at the Department of Applied Physics and Science Education on April 1.
    Read more
    f.L.t.R.: Daniël Lakens and Peter Zijlstra. Photo left by Bart van Overbeeke.
    February 28, 2025
    NWO Vici grants awarded to Daniël Lakens and Peter Zijlstra
    Two TU/e scientists have received a prestigious Vici grant from the NWO. One for research on meaningful ways to interpret effects in psychology (Lakens) and...
    Read more
    More news
    [Translate to English:]
    Max Schelling Publishes Study on Cooling-Dependent Crystallization in Microgels in Soft Matter
    August 29, 2024
    Continuous biosensing using free particle motion
    June 11, 2024
    [Translate to English:]
    Golden help to track fast biomolecular processes
    April 11, 2024
    Real-time continuous biosensing by particle motion analysis
    December 14, 2023

    Education

    Check out all our courses

    The research group Molecular Biosensing for Medical Diagnostics provides courses and projects in the bachelor's and master's programs of the departments of Biomedical Engineering and Applied Physics. Furthermore, we offer a broad range of projects for students to work on in the research group.

    PhD Theses

    (Defense 1 April 2025)

    Vincenzo Lamberti

    Plasmon-mediated pathways for single-molecule fluorescence biosensing
    (Defense 19 March 2025)

    Ana Ortiz Pérez

    Imaging-guided high-throughput formulation and screening of nanoparticles
    (Defense 6 June 2024)

    Alissa Buskermolen

    Continuous biosensing by free particle motion: A gateway to dynamic immunomonitoring
    (Defence 9 April 2024)

    Sjoerd Nooteboom

    A golden key to microseconds: Plasmon-Enhanced Single-Molecule Fluorescence for Ultrafast Biomolecular Dynamics
    (Defence 7 November 2023)

    Laura van Smeden

    Continuous monitoring of health markers: A study on BPM immunoassays and microdialysis
    (Defence 13 December 2023)

    Max Bergkamp

    Real-time analysis of particle motion for continuous biosensing with single-molecule resolution
    (Defence 22 March 2023)

    Emmanouil Archontakis

    Quantification of Nanomaterials with Spectrally-Resolved Super-Resolution Microscopy
    (Defence 10 march 2023)

    Roger Riera Brillas

    PAINTing receptors: a quantitative single-molecule view on cell membrane receptors
    (Defence 16 september 2022)

    Laura Woythe

    Molecular Mapping of Nanoparticle Targeting: A Super-Resolved Journey

    (Defence 22 februari 2022)

    Yu-Ting Lin

    Biofunctionalization strategies for continuous monitoring biosensors

    (Defence 14 januari 2022)

    Rafiq Lubken

    Continuous biomolecular sensing with single-molecule resolution: Explorations of bioanalytical functionalities
    (Defence 15 december 2020)

    Michael Beuwer

    Correlative microscopic characterization of nanoscale assemblies at interfaces
    (Defence 19 June 2020)

    Yuyang Wang

    A plasmonic nanotorch: pushing plasmon-enhanced fluorescence for applications in single-molecule enzymology
    (Defence 30 September 2020)

    Matěj Horácek

    A plasmon ruler to probe conformational transitions of single molecules in real-time
    (Defence 12 June 2020)

    Max Scheepers

    Inter-particle biomolecular reactivity: how aggregation rates and selectivity are influenced by charge, surface crowders and multivalent interactions

    Video on Plasmonic Biosensing using Metal Nanoparticles

    Metal nanoparticles provide the possibility to detect single molecules without the need for labeling, enabling the direct detection of non-absorbing species [1]. A molecule that binds to receptors on the surface of a particle induces a change in the local refractive index that in turn results in a change of color due to a shift of the plasmon resonance [2,3]. This animation illustrates the real-time detection of plasmon shifts induced by molecules binding to functionalized single gold nanorods. The plasmon shifts are measured by monitoring scattering intensities of many particles simultaneously and in real-time [4].

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