Departments of Applied Physics / Biomedical Engineering

Molecular Biosensing

The MBx group develops technologies based on micro- and nanoparticles for monitoring patients and for treating diseases. Towards this goal, the unique approach of MBx is to use advanced optical imaging techniques that quantify molecular processes with single molecule resolution within complex biomacromolecular environments.

Quantify molecular processes with single molecule resolution

The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.

Research Areas

Plasmonic Sensing

The Molecular Plasmonics group develops nanophotonic and plasmonic approaches for single-molecule detection using a single particle−single…

Research Area of Molecular Biosensing for Medical Diagnostics

Biosensing by Particle Motion

Research Area of Molecular Biosensing for Medical Diagnostics

Nanoscopy for Nanomedicine

The development of nanostructured materials to achieve innovation in healthcare, i.e. nanomedicine, is one of the great challenges in…

Former research areas

UPCOMING TECHNOLOGIES FOR CLINICAL IMMUNOLOGY

  • 05 Sep
    26 Sep

    World Press Photo Tentoonstelling 2023

    September 5, 2023 7:00 AM / Atlas building, begane grond (ground level)

  • 06 Sep
    26 Sep

    Guided Tours: World Press Photo Exhibition 20

    September 6, 2023 12:30 PM / Atlas building, ground floor

  • 25 Sep

    LEVEL UP 2023

    September 25, 2023 9:00 AM / Evoluon Eindhoven

  • 26 Sep
    One layer at a time

    PhD defense Daniëlle Scheepers

    September 26, 2023 / TU/e Campus

  • 26 Sep
    Protein-sized amphiphilic polymeric nanoparticles

    PhD defense Linlin Deng

    September 26, 2023 / TU/e Campus

  • 27 Sep
    Deep Learning Techniques for Multi-Dimensional Medical Image Analysis

    PhD defense Farhad Ghazvinian Zanjani

    September 27, 2023 / TU/e Campus

  • 27 Sep
    Numerical Methods for the Hyperbolic Monge-Ampère Equation with Applications to Optical Design

    PhD defense Maikel Wilhelmus Marinus Cornelus Bertens

    September 27, 2023 / TU/e Campus

  • 28 Sep
    29 Sep
    The academic celebration of the year

    MomenTUm

    September 28, 2023 7:00 PM / TU/e campus

  • 29 Sep
    Necessity for better membranes in water electrolysis and CO2 electrolysis

    EIRES Lunch Lecture

    12h00-13h00 | with David A. Vermaas (online)

  • 03 Oct
    June 14, 2023

    HighTech Chemistry Event

    October 3, 2023 9:30 AM / Blauwe Zaal

  • 04 Oct
    Non-Oxidative Coupling of Methane over Heterogeneous Catalysts: Understanding Surface and Gas-Phase Processes

    PhD defense Hao Zhang

    October 4, 2023 / TU/e Campus

  • 04 Oct
    Make Differences Count

    PhD defense Janna Heynen-Behnke

    October 4, 2023 / TU/e Campus

    • Work with us!

    Building a better future for our global society? Join our research team and be part of the thriving community at Eindhoven University of Technology.

    Working at the department of Biomedical Engineering or Applied Physics

    We are continuously looking for enthusiastic and motivated students and postdocs. If you would like to work in a great environment at TU/e, please contact one of the staff members for more information.

     

    Meet some of our Researchers

    Associate Professor

    Peter Zijlstra

    Doctoral Candidate

    Chris Vu

    Full Professor

    Menno Prins

    Education and Research Technician (Design and Development)

    Yuyang Wang

    Associate Professor

    Lorenzo Albertazzi

    Assistant Professor

    Arthur de Jong

    Former Doctoral Candidate

    Laura van Smeden

    Associate Professor

    Leo van Ijzendoorn

    Postdoc

    Mathias Dolci

    Doctoral Candidate-TA

    Marrit Tholen

    Recent Publications

    Our most recent peer reviewed publications

    About the research group

    News

    June 1, 2023
    With light into the nanoworld
    How optical microscopes allow detailed investigations of nanoparticles for biosensing
    Read more
    October 18, 2022
    Continuous biomarker monitoring with single molecule resolution by measuring free particle motion
    Publication in Nature Communications for TU/e researchers in the field of Molecular Biosensing.
    Read more
    More news
    Selective cancer nanoparticle targeting under the microscope
    September 20, 2022
    Testing day and night an option with pocket lab
    January 13, 2022
    Get ready for the biosensor future
    November 5, 2021
    Being a researcher and entrepreneur means playing chess on several boards at the same time
    January 15, 2021

    Education

    Check out all our courses

    The research group Molecular Biosensing for Medical Diagnostics provides courses and projects in the bachelor's and master's programs of the departments of Biomedical Engineering and Applied Physics. Furthermore, we offer a broad range of projects for students to work on in the research group.

    PhD Theses

    (Defence 22 March 2023)

    Emmanouil Archontakis

    Quantification of Nanomaterials with Spectrally-Resolved Super-Resolution Microscopy
    (Defence 10 march 2023)

    Roger Riera Brillas

    PAINTing receptors: a quantitative single-molecule view on cell membrane receptors
    (Defence 16 september 2022)

    Laura Woythe

    Molecular Mapping of Nanoparticle Targeting: A Super-Resolved Journey

    (Defence 22 februari 2022)

    Yu-Ting Lin

    Biofunctionalization strategies for continuous monitoring biosensors

    (Defence 14 januari 2022)

    Rafiq Lubken

    Continuous biomolecular sensing with single-molecule resolution: Explorations of bioanalytical functionalities
    (Defence 15 december 2020)

    Michael Beuwer

    Correlative microscopic characterization of nanoscale assemblies at interfaces
    (Defence 19 June 2020)

    Yuyang Wang

    A plasmonic nanotorch: pushing plasmon-enhanced fluorescence for applications in single-molecule enzymology
    (Defence 30 September 2020)

    Matěj Horácek

    A plasmon ruler to probe conformational transitions of single molecules in real-time
    (Defence 12 June 2020)

    Max Scheepers

    Inter-particle biomolecular reactivity: how aggregation rates and selectivity are influenced by charge, surface crowders and multivalent interactions
    (Defence: 23 January 2020)

    Natalia Feiner Gracia

    Reaching the tumour: nanoscopy study of nanoparticles in the biological environment
    (Defence: 19 December 2019)

    Christian Moerland

    Torque on magnetic particles for biomedical applications
    (Defence: 7 November 2016)

    Fabiola Azucena Gutierrez Mejia

    Proteins with a Twist: Torsion Profiling of Proteins at the Single Molecule Level
    (Defence: 31 October 2018)

    Roland van Vliembergen

    Optical Scattering of Rotating Dimers for Biosensing Applications
    (Defence: 19 April 2017)

    Emiel Visser

    Biosensing Based on Tethered Particle Motion
    (Defence: 28 September 2016)

    Stefano Cappelli

    Magnetic Particles at Fluid-Fluid Interfaces: Microrheology, Interaction and Wetting

    Video on Plasmonic Biosensing using Metal Nanoparticles

    Metal nanoparticles provide the possibility to detect single molecules without the need for labeling, enabling the direct detection of non-absorbing species [1]. A molecule that binds to receptors on the surface of a particle induces a change in the local refractive index that in turn results in a change of color due to a shift of the plasmon resonance [2,3]. This animation illustrates the real-time detection of plasmon shifts induced by molecules binding to functionalized single gold nanorods. The plasmon shifts are measured by monitoring scattering intensities of many particles simultaneously and in real-time [4].

    Contact