Departments of Applied Physics / Biomedical Engineering

Molecular Biosensing

The MBx group develops technologies based on micro- and nanoparticles for monitoring patients and for treating diseases. Towards this goal, the unique approach of MBx is to use advanced optical imaging techniques that quantify molecular processes with single molecule resolution within complex biomacromolecular environments.

Quantify molecular processes with single molecule resolution

The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.

Research Areas

UPCOMING TECHNOLOGIES FOR CLINICAL IMMUNOLOGY

  • 02 Apr
    Liquid injection into dense gas fluidized beds

    PhD defense

    April 2, 2024 / TU/e Campus

  • 02 Apr
    Towards Nanoscale Torque Revolution

    PhD defense Jianing Li

    April 2, 2024 / TU/e Campus

  • 02 Apr
    Adenomyosis

    PhD defense Connie O. Rees

    April 2, 2024 / TU/e Campus

  • 03 Apr
    Structural and Chemical Promoters for In2O3-Catalyzed CO2 Hydrogenation to Methanol

    PhD defense Liang Liu

    April 3, 2024 / TU/e Campus

  • 03 Apr

    Debussy and Piazzolla for lunch

    April 3, 2024 12:40 PM / Blauwe Zaal, Auditorium

  • 03 Apr
    Exploring variable viscosity effects in droplet collision dynamics in complex fluid systems

    PhD defense Penbe Merve Durubal

    April 3, 2024 / TU/e Campus

  • 03 Apr
    [Translate to English:]

    Roundtables on curriculum redesign PART 2

    April 3, 2024 12:30 PM / Vertigo 5.07

  • 04 Apr
    Density and Combinatorial Structure of Error-Correcting Codes

    PhD defense Anina Gruica

    April 4, 2024 / TU/e Campus

  • 04 Apr
    Modeling the formation and mechanics of hybrid hydrogels

    PhD defense Chiara Raffaelli

    April 4, 2024 / TU/e Campus

  • 04 Apr

    IE&ES and ID Student Lunch Meeting on Sustainability

    April 4, 2024 12:30 PM / Atlas 1.654

  • 04 Apr
    [Translate to English:]
    January 4, 2024
    For TU/e staff only

    innovation Space CBL Train-the-Trainer Session (04-04-24)

    Join our innovation Space CBL Train-the-Trainer Session, tailored specifically for teacher supporters like you! In this 3-hour session, you…

  • 04 Apr
    oranje voetbalfan
    MSc students of all departments are welcome!

    AI & Football Graduation Projects

    Are you passionate about both AI and football? Want to know how you can do your MSc graduation project at TU/e and KNVB on AI?

  • Work with us!

    Building a better future for our global society? Join our research team and be part of the thriving community at Eindhoven University of Technology.

    Working at the department of Biomedical Engineering or Applied Physics

    We are continuously looking for enthusiastic and motivated students and postdocs. If you would like to work in a great environment at TU/e, please contact one of the staff members for more information.

     

    Meet some of our Researchers

    About the research group

    News

    Education

    Check out all our courses

    The research group Molecular Biosensing for Medical Diagnostics provides courses and projects in the bachelor's and master's programs of the departments of Biomedical Engineering and Applied Physics. Furthermore, we offer a broad range of projects for students to work on in the research group.

    PhD Theses

    (Defence 7 November 2023)

    Laura van Smeden

    Continuous monitoring of health markers: A study on BPM immunoassays and microdialysis

    (Defence 13 December 2023)

    Max Bergkamp

    Real-time analysis of particle motion for continuous biosensing with single-molecule resolution

    (Defence 22 March 2023)

    Emmanouil Archontakis

    Quantification of Nanomaterials with Spectrally-Resolved Super-Resolution Microscopy

    (Defence 10 march 2023)

    Roger Riera Brillas

    PAINTing receptors: a quantitative single-molecule view on cell membrane receptors

    (Defence 16 september 2022)

    Laura Woythe

    Molecular Mapping of Nanoparticle Targeting: A Super-Resolved Journey

    (Defence 22 februari 2022)

    Yu-Ting Lin

    Biofunctionalization strategies for continuous monitoring biosensors

    (Defence 14 januari 2022)

    Rafiq Lubken

    Continuous biomolecular sensing with single-molecule resolution: Explorations of bioanalytical functionalities

    (Defence 15 december 2020)

    Michael Beuwer

    Correlative microscopic characterization of nanoscale assemblies at interfaces

    (Defence 19 June 2020)

    Yuyang Wang

    A plasmonic nanotorch: pushing plasmon-enhanced fluorescence for applications in single-molecule enzymology

    (Defence 30 September 2020)

    Matěj Horácek

    A plasmon ruler to probe conformational transitions of single molecules in real-time

    (Defence 12 June 2020)

    Max Scheepers

    Inter-particle biomolecular reactivity: how aggregation rates and selectivity are influenced by charge, surface crowders and multivalent interactions

    (Defence: 23 January 2020)

    Natalia Feiner Gracia

    Reaching the tumour: nanoscopy study of nanoparticles in the biological environment

    (Defence: 19 December 2019)

    Christian Moerland

    Torque on magnetic particles for biomedical applications

    (Defence: 7 November 2016)

    Fabiola Azucena Gutierrez Mejia

    Proteins with a Twist: Torsion Profiling of Proteins at the Single Molecule Level

    (Defence: 31 October 2018)

    Roland van Vliembergen

    Optical Scattering of Rotating Dimers for Biosensing Applications

    Video on Plasmonic Biosensing using Metal Nanoparticles

    Metal nanoparticles provide the possibility to detect single molecules without the need for labeling, enabling the direct detection of non-absorbing species [1]. A molecule that binds to receptors on the surface of a particle induces a change in the local refractive index that in turn results in a change of color due to a shift of the plasmon resonance [2,3]. This animation illustrates the real-time detection of plasmon shifts induced by molecules binding to functionalized single gold nanorods. The plasmon shifts are measured by monitoring scattering intensities of many particles simultaneously and in real-time [4].

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