Departments of Applied Physics / Biomedical Engineering

Molecular Biosensing

The MBx group develops technologies based on micro- and nanoparticles for monitoring patients and for treating diseases. Towards this goal, the unique approach of MBx is to use advanced optical imaging techniques that quantify molecular processes with single molecule resolution within complex biomacromolecular environments.

Quantify molecular processes with single molecule resolution

The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.

Research Areas


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Building a better future for our global society? Join our research team and be part of the thriving community at Eindhoven University of Technology.

Working at the department of Biomedical Engineering or Applied Physics

We are continuously looking for enthusiastic and motivated students and postdocs. If you would like to work in a great environment at TU/e, please contact one of the staff members for more information.


Meet some of our Researchers

About the research group



Check out all our courses

The research group Molecular Biosensing for Medical Diagnostics provides courses and projects in the bachelor's and master's programs of the departments of Biomedical Engineering and Applied Physics. Furthermore, we offer a broad range of projects for students to work on in the research group.

PhD Theses

(Defence 22 March 2023)

Emmanouil Archontakis

Quantification of Nanomaterials with Spectrally-Resolved Super-Resolution Microscopy

(Defence 10 march 2023)

Roger Riera Brillas

PAINTing receptors: a quantitative single-molecule view on cell membrane receptors

(Defence 16 september 2022)

Laura Woythe

Molecular Mapping of Nanoparticle Targeting: A Super-Resolved Journey

(Defence 22 februari 2022)

Yu-Ting Lin

Biofunctionalization strategies for continuous monitoring biosensors

(Defence 14 januari 2022)

Rafiq Lubken

Continuous biomolecular sensing with single-molecule resolution: Explorations of bioanalytical functionalities

(Defence 15 december 2020)

Michael Beuwer

Correlative microscopic characterization of nanoscale assemblies at interfaces

(Defence 19 June 2020)

Yuyang Wang

A plasmonic nanotorch: pushing plasmon-enhanced fluorescence for applications in single-molecule enzymology

(Defence 30 September 2020)

Matěj Horácek

A plasmon ruler to probe conformational transitions of single molecules in real-time

(Defence 12 June 2020)

Max Scheepers

Inter-particle biomolecular reactivity: how aggregation rates and selectivity are influenced by charge, surface crowders and multivalent interactions

(Defence: 23 January 2020)

Natalia Feiner Gracia

Reaching the tumour: nanoscopy study of nanoparticles in the biological environment

(Defence: 19 December 2019)

Christian Moerland

Torque on magnetic particles for biomedical applications

(Defence: 7 November 2016)

Fabiola Azucena Gutierrez Mejia

Proteins with a Twist: Torsion Profiling of Proteins at the Single Molecule Level

(Defence: 31 October 2018)

Roland van Vliembergen

Optical Scattering of Rotating Dimers for Biosensing Applications

(Defence: 19 April 2017)

Emiel Visser

Biosensing Based on Tethered Particle Motion

(Defence: 28 September 2016)

Stefano Cappelli

Magnetic Particles at Fluid-Fluid Interfaces: Microrheology, Interaction and Wetting

Video on Plasmonic Biosensing using Metal Nanoparticles

Metal nanoparticles provide the possibility to detect single molecules without the need for labeling, enabling the direct detection of non-absorbing species [1]. A molecule that binds to receptors on the surface of a particle induces a change in the local refractive index that in turn results in a change of color due to a shift of the plasmon resonance [2,3]. This animation illustrates the real-time detection of plasmon shifts induced by molecules binding to functionalized single gold nanorods. The plasmon shifts are measured by monitoring scattering intensities of many particles simultaneously and in real-time [4].