Quantify molecular processes with single molecule resolution
The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.
Read moreResearch Areas
Work with us!
Building a better future for our global society? Join our research team and be part of the thriving community at Eindhoven University of Technology.
Working at the department of Biomedical Engineering or Applied Physics
We are continuously looking for enthusiastic and motivated students and postdocs. If you would like to work in a great environment at TU/e, please contact one of the staff members for more information.
Meet some of our Researchers
Recent Publications
Our most recent peer reviewed publications
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Valency and affinity control of aptamer-conjugated nanoparticles for selective cancer cell targeting
Journal of Controlled Release (2023) -
Precision and accuracy of receptor quantification on synthetic and biological surfaces using DNA-PAINT
ACS Sensors (2023) -
Single-Particle Functionality Imaging of Antibody-Conjugated Nanoparticles in Complex Media
ACS Applied Bio Materials (2023) -
Spectrally PAINTing a Single Chain Polymeric Nanoparticle at Super-Resolution
Journal of the American Chemical Society (2022) -
Enabling Spectrally Resolved Single-Molecule Localization Microscopy at High Emitter Densities
Nano Letters (2022)
News






Education
Check out all our courses
The research group Molecular Biosensing for Medical Diagnostics provides courses and projects in the bachelor's and master's programs of the departments of Biomedical Engineering and Applied Physics. Furthermore, we offer a broad range of projects for students to work on in the research group.
PhD Theses
Video on Plasmonic Biosensing using Metal Nanoparticles
Metal nanoparticles provide the possibility to detect single molecules without the need for labeling, enabling the direct detection of non-absorbing species [1]. A molecule that binds to receptors on the surface of a particle induces a change in the local refractive index that in turn results in a change of color due to a shift of the plasmon resonance [2,3]. This animation illustrates the real-time detection of plasmon shifts induced by molecules binding to functionalized single gold nanorods. The plasmon shifts are measured by monitoring scattering intensities of many particles simultaneously and in real-time [4].
Contact
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Visiting address
FluxGroene Loper 195612 AE EindhovenNetherlands -
Visiting address
FluxGroene Loper 195612 AE EindhovenNetherlands -
Postal address
Department of Biomedical Engineering & Department of Applied PhysicsP.O.Box 5135600 MB EindhovenNetherlands -
Postal address
Department of Biomedical Engineering & Department of Applied PhysicsP.O.Box 5135600 MB EindhovenNetherlands -
SecretaryJ.J.M.Levering@ tue.nl
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Secretaryw.a.m.v.lieshout@ tue.nl