Departments of Applied Physics / Biomedical Engineering

Molecular Biosensing

The MBx group develops technologies based on micro- and nanoparticles for monitoring patients and for treating diseases. Towards this goal, the unique approach of MBx is to use advanced optical imaging techniques that quantify molecular processes with single molecule resolution within complex biomacromolecular environments.

Quantify molecular processes with single molecule resolution

The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.

Research Areas


  • 24 Mar

    The Last of Us Lunch Lecture

    March 24, 2023 12:30 PM / de Filmzaal/Lounge of the Zwarte Doos

  • 24 Mar
    Membrane‐assisted direct dehydrogenation technology for light olefins production

    PhD defense Camilla Brencio

    March 24, 2023 / TU/e Campus

  • 24 Mar
    Unraveling the physics of the hygro-expansion of paper

    PhD defense Nicolaas Hendrikus Vonk

    March 24, 2023 / TU/e Campus

  • 24 Mar
    [Translate to English:]

    Inaugural lecture prof.dr. Michel Chaudron

    March 24, 2023 4:00 PM / Blauwe Zaal

  • 24 Mar
    28 Mar
    March 13, 2023
    Departmental Webinar series for TU/e Faculty and Staff

    JoVE in Teaching and Practical Training

    March 24, 2023 / Online

  • 27 Mar
    AI for the real world

    Women in Data Science Eindhoven 2023

    After a succesfull in-person event last year, Women in Data Science (WiDS) Eindhoven will return on Monday 27 March 2023.

  • 28 Mar
    Neuron data
    Synapses and Silicon: Exploring the Intersection of AI and Neuroscience

    EAISI AI Symposium

    Symposium in honor of the opening of Neuron: Synapses and Silicon: exploring the intersection of AI and neuroscience.

  • 28 Mar

    Official Opening Neuron building

    The festive opening of the Neuron building is intended for all TU/e students, staff and invitees. This building will house lecture rooms and…

  • 28 Mar
    Formalization, Analysis, and Sampled-Data Design of Hybrid Integrator-Gain Systems

    PhD defense Bardia Sharif

    March 28, 2023 / TU/e Campus

  • 29 Mar
    Break the Code?

    PhD defense Lina Maria Ochoa Venegas

    March 29, 2023 / TU/e Campus

  • 29 Mar

    The bright side of life

    March 29, 2023 12:40 PM / Blauwe Zaal, Auditorium

  • 29 Mar
    Aspects of Synthesis, Structure and Catalytic Performance of Alumina Supported NiMo Hydrotreating Catalysts

    PhD defense Mengyan Li

    March 29, 2023 / TU/e Campus

  • Work with us!

    Building a better future for our global society? Join our research team and be part of the thriving community at Eindhoven University of Technology.

    Working at the department of Biomedical Engineering or Applied Physics

    We are continuously looking for enthusiastic and motivated students and postdocs. If you would like to work in a great environment at TU/e, please contact one of the staff members for more information.


    Meet some of our Researchers

    About the research group



    Check out all our courses

    The research group Molecular Biosensing for Medical Diagnostics provides courses and projects in the bachelor's and master's programs of the departments of Biomedical Engineering and Applied Physics. Furthermore, we offer a broad range of projects for students to work on in the research group.

    PhD Theses

    (Defence 16 september 2022)

    Laura Woythe

    Molecular Mapping of Nanoparticle Targeting: A Super-Resolved Journey

    (Defence 22 februari 2022)

    Yu-Ting Lin

    Biofunctionalization strategies for continuous monitoring biosensors

    (Defence 14 januari 2022)

    Rafiq Lubken

    Continuous biomolecular sensing with single-molecule resolution: Explorations of bioanalytical functionalities

    (Defence 15 december 2020)

    Michael Beuwer

    Correlative microscopic characterization of nanoscale assemblies at interfaces

    (Defence 19 June 2020)

    Yuyang Wang

    A plasmonic nanotorch: pushing plasmon-enhanced fluorescence for applications in single-molecule enzymology

    (Defence 30 September 2020)

    Matěj Horácek

    A plasmon ruler to probe conformational transitions of single molecules in real-time

    (Defence 12 June 2020)

    Max Scheepers

    Inter-particle biomolecular reactivity: how aggregation rates and selectivity are influenced by charge, surface crowders and multivalent interactions

    (Defence: 23 January 2020)

    Natalia Feiner Gracia

    Reaching the tumour: nanoscopy study of nanoparticles in the biological environment

    (Defence: 19 December 2019)

    Christian Moerland

    Torque on magnetic particles for biomedical applications

    (Defence: 7 November 2016)

    Fabiola Azucena Gutierrez Mejia

    Proteins with a Twist: Torsion Profiling of Proteins at the Single Molecule Level

    (Defence: 31 October 2018)

    Roland van Vliembergen

    Optical Scattering of Rotating Dimers for Biosensing Applications

    (Defence: 19 April 2017)

    Emiel Visser

    Biosensing Based on Tethered Particle Motion

    (Defence: 28 September 2016)

    Stefano Cappelli

    Magnetic Particles at Fluid-Fluid Interfaces: Microrheology, Interaction and Wetting

    (Defence: 2 June 2014)

    Alexander van Reenen

    Dynamic Magnetic Particle Actuation for Integrated Lab-on-Chip Biosensing

    (Defence: 1 January 2013)

    Matthias Irmscher

    Mechanics of the Contact Interface between Cells and Functionalized Surfaces

    Video on Plasmonic Biosensing using Metal Nanoparticles

    Metal nanoparticles provide the possibility to detect single molecules without the need for labeling, enabling the direct detection of non-absorbing species [1]. A molecule that binds to receptors on the surface of a particle induces a change in the local refractive index that in turn results in a change of color due to a shift of the plasmon resonance [2,3]. This animation illustrates the real-time detection of plasmon shifts induced by molecules binding to functionalized single gold nanorods. The plasmon shifts are measured by monitoring scattering intensities of many particles simultaneously and in real-time [4].