Department of Biomedical Engineering

Molecular Biosensing for Medical Diagnostics

The MBx group develops technologies based on micro- and nanoparticles for monitoring patients and for treating diseases. Towards this goal, the unique approach of MBx is to use advanced optical imaging techniques that quantify molecular processes with single molecule resolution within complex biomacromolecular environments.

Quantify molecular processes with single molecule resolution

The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.

Research Areas

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Building a better future for our global society? Join our research team and be part of the thriving community at Eindhoven University of Technology.

Working at the department of Biomedical Engineering or Applied Physics

We are continuously looking for enthusiastic and motivated students and postdocs. If you would like to work in a great environment at TU/e, please contact one of the staff members for more information.

9 staff positions for female candidates in the Department of Applied Physics

All positions are open from May 15, 2019, and are open only to female candidates in the framework of the new Irène Curie Fellowship program of TU/e. Review of applications will begin immediately upon receipt, and continue until the positions are filled, with the last date for applications being November 15, 2019.

Meet some of our Researchers

About the research group


Student opportunities

The research group Molecular Biosensing for Medical Diagnostics provides courses and projects in the bachelor's and master's programs of the departments of Biomedical Engineering and Applied Physics. Furthermore, we offer a broad range of projects for students to work on in the research group.

PhD Theses

(Defence: 31 October 2018)

Roland van Vliembergen

Optical Scattering of Rotating Dimers for Biosensing Applications

(Defence: 19 April 2017)

Emiel Visser

Biosensing Based on Tethered Particle Motion

(Defence: 7 November 2016)

Fabiola Azucena Gutierrez Mejia

Proteins with a Twist: Torsion Profiling of Proteins at the Single Molecule Level

(Defence: 28 September 2016)

Stefano Cappelli

Magnetic Particles at Fluid-Fluid Interfaces: Microrheology, Interaction and Wetting

(Defence: 2 June 2014)

Alexander van Reenen

Dynamic Magnetic Particle Actuation for Integrated Lab-on-Chip Biosensing

(Defence: 1 January 2013)

Matthias Irmscher

Mechanics of the Contact Interface between Cells and Functionalized Surfaces

(Defence: 1 January 2013)

Marijn Kemper

Non-Specific Protein-Surface Interactions in the Context of Particle Based Biosensors

(Defence: 1 January 2013)

H.M. van Zijp

Study of Methods for Platelet Function Testing in the Perspective of Lab-on-Chip Applications

(Defence: 1 January 2012)

Andrea Ranzoni

Rotational Actuation of Magnetic Nanoparticle Clusters for Solution-Based Biosensing

(Defence: 1 January 2011)

Remco den Dulk

Magneto-Capillary Valve for Integrated Biological Sample Preparation

(Defence: 1 January 2010)

Roy Derks

Particle Dynamics in Magneto-Fluidic Microsystems

(Defence: 1 January 2010)

Kim van Ommering

Dynamics of Individual Magnetic Particles near a Biosensor Surface

(Defence: 1 January 2009)

Francis Fahrni

Magnetic Polymer Actuators for Microfluidics

(Defence: 1 January 2009)

X.J.A. Janssen

Magnetic Particle Actuation for Functional Biosensors

(Defence: 1 January 2006)

Charlotte Kjellander

Multilayer Optical Switches by Photopolymerization-Induced Phase Separation

Video on Plasmonic Biosensing using Metal Nanoparticles

Metal nanoparticles provide the possibility to detect single molecules without the need for labeling, enabling the direct detection of non-absorbing species [1]. A molecule that binds to receptors on the surface of a particle induces a change in the local refractive index that in turn results in a change of color due to a shift of the plasmon resonance [2,3]. This animation illustrates the real-time detection of plasmon shifts induced by molecules binding to functionalized single gold nanorods. The plasmon shifts are measured by monitoring scattering intensities of many particles simultaneously and in real-time [4].