Quantify molecular processes with single molecule resolution
The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.Read more
Particle Functionalization and Characterization
The detection and study of specific proteins in a heterogeneous solution requires functionalized probe particles that have a strong affinity...
A major advantage of studying biochemical interactions at the level of individual molecules is the possibility to measure properties that...
Torque Spectroscopy of Single Proteins and Membranes
We are developing torsion profiling techniques for protein and membrane characterization and for nanomechanical studies on...
Particle Actuation for Integrated Biosensing
The aging population and increases in chronic diseases put high pressure on the healthcare system, which drives a need for easy to use and...
Meet some of our Researchers
Leo van Ijzendoorn
Arthur de Jong
Our most recent peer reviewed publications
Super-resolution imaging of structure, molecular composition, and stability of single oligonucleotide polyplexesNano Letters (2019)
Super-resolution microscopy on single particles at fluid interfaces reveals their wetting properties and interfacial deformationsNanoscale (2019)
A stochastic view on surface inhomogeneity of nanoparticlesNature Communications (2019)
Super-resolution microscopy reveals significant impact of M2e-specific monoclonal antibodies on influenza A virus filament formation at the host cell surfaceScientific Reports (2019)
Super-resolution microscopy as a powerful tool to study complex synthetic materialsNature Reviews Chemistry (2019)
The research group Molecular Biosensing for Medical Diagnostics provides courses and projects in the bachelor's and master's programs of the departments of Biomedical Engineering and Applied Physics. Furthermore, we offer a broad range of projects for students to work on in the research group.
Roland van Vliembergen
Optical Scattering of Rotating Dimers for Biosensing Applications
Biosensing Based on Tethered Particle Motion
Fabiola Azucena Gutierrez Mejia
Proteins with a Twist: Torsion Profiling of Proteins at the Single Molecule Level
Magnetic Particles at Fluid-Fluid Interfaces: Microrheology, Interaction and Wetting
Alexander van Reenen
Dynamic Magnetic Particle Actuation for Integrated Lab-on-Chip Biosensing
Mechanics of the Contact Interface between Cells and Functionalized Surfaces
Non-Specific Protein-Surface Interactions in the Context of Particle Based Biosensors
H.M. van Zijp
Study of Methods for Platelet Function Testing in the Perspective of Lab-on-Chip Applications
Rotational Actuation of Magnetic Nanoparticle Clusters for Solution-Based Biosensing
Remco den Dulk
Magneto-Capillary Valve for Integrated Biological Sample Preparation
Particle Dynamics in Magneto-Fluidic Microsystems
Kim van Ommering
Dynamics of Individual Magnetic Particles near a Biosensor Surface
Magnetic Polymer Actuators for Microfluidics
Magnetic Particle Actuation for Functional Biosensors
Multilayer Optical Switches by Photopolymerization-Induced Phase Separation
Video on Plasmonic Biosensing using Metal Nanoparticles
Metal nanoparticles provide the possibility to detect single molecules without the need for labeling, enabling the direct detection of non-absorbing species . A molecule that binds to receptors on the surface of a particle induces a change in the local refractive index that in turn results in a change of color due to a shift of the plasmon resonance [2,3]. This animation illustrates the real-time detection of plasmon shifts induced by molecules binding to functionalized single gold nanorods. The plasmon shifts are measured by monitoring scattering intensities of many particles simultaneously and in real-time .
Building a better future for our global society?
Join our research team and be part of the thriving community at Eindhoven University of Technology.
We are continuously looking for enthusiastic and motivated students and postdocs. If you would like to work in a great environment at TU/e please contact one of the staff members for more information.