Departments of Applied Physics / Biomedical Engineering

Molecular Biosensing

The MBx group develops technologies based on micro- and nanoparticles for monitoring patients and for treating diseases. Towards this goal, the unique approach of MBx is to use advanced optical imaging techniques that quantify molecular processes with single molecule resolution within complex biomacromolecular environments.

Quantify molecular processes with single molecule resolution

The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.

Research Areas


  • 08 Jun
    09 Jun
    [Translate to English:]

    Dutch Technology Festival

    June 8, 2023 9:00 AM / Klokgebouw, Strijp S Eindhoven

  • 09 Jun
    Statistical Monitoring Procedures for High-Purity Manufacturing Processes

    PhD defense Caterina Rizzo

    June 9, 2023 / TU/e Campus

  • 09 Jun
    Restorative value of the urban greenscape

    PhD defense Robert Paul van Dongen

    June 9, 2023 / TU/e Campus

  • 09 Jun
    The people's aspect of energy transition in buildings: data, digital tools, behaviour

    EIRES Lunch lecture

    12h00-13h00 with Ioulia Ossokina & Theo Arentze

  • 12 Jun
    16 Jun

    TU/e Green Week 2023

    June 12, 2023 / Various buildings around campus

  • 13 Jun
    Class Association Rule Models for Predicting Transportation Mode Choice

    PhD defense Jiajia Zhang

    June 13, 2023 / TU/e Campus

  • 13 Jun
    Extra curricular experience

    Meet the student teams

    Want to do more than just studying? Join a student team and put theory into practice, develop your (soft) skills and work on innovations!

  • 13 Jun
    Stabilization of 14-3-3 protein-protein interactions

    PhD defense Bente Aminhan Somsen

    June 13, 2023 / TU/e Campus

  • 13 Jun
    Towards Plasma Charging Visualization

    PhD defense Mohammad Hasani

    June 13, 2023 / TU/e Campus

  • 13 Jun

    Transformative Research for Sustainability

    June 13, 2023 10:45 AM / Filmzaal de Zwarte Doos

  • 14 Jun
    Neuron and data
    Seminar on organic and electrochemical electronics for neuromorphic computing and sensing

    Neuromorphic computing seminar

    June 14, 2023 9:00 AM / TU/e campus | Neuron building, room 0.262

  • 14 Jun
    March 22, 2023


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    Building a better future for our global society? Join our research team and be part of the thriving community at Eindhoven University of Technology.

    Working at the department of Biomedical Engineering or Applied Physics

    We are continuously looking for enthusiastic and motivated students and postdocs. If you would like to work in a great environment at TU/e, please contact one of the staff members for more information.


    Meet some of our Researchers

    About the research group



    Check out all our courses

    The research group Molecular Biosensing for Medical Diagnostics provides courses and projects in the bachelor's and master's programs of the departments of Biomedical Engineering and Applied Physics. Furthermore, we offer a broad range of projects for students to work on in the research group.

    PhD Theses

    (Defence 22 March 2023)

    Emmanouil Archontakis

    Quantification of Nanomaterials with Spectrally-Resolved Super-Resolution Microscopy

    (Defence 10 march 2023)

    Roger Riera Brillas

    PAINTing receptors: a quantitative single-molecule view on cell membrane receptors

    (Defence 16 september 2022)

    Laura Woythe

    Molecular Mapping of Nanoparticle Targeting: A Super-Resolved Journey

    (Defence 22 februari 2022)

    Yu-Ting Lin

    Biofunctionalization strategies for continuous monitoring biosensors

    (Defence 14 januari 2022)

    Rafiq Lubken

    Continuous biomolecular sensing with single-molecule resolution: Explorations of bioanalytical functionalities

    (Defence 15 december 2020)

    Michael Beuwer

    Correlative microscopic characterization of nanoscale assemblies at interfaces

    (Defence 19 June 2020)

    Yuyang Wang

    A plasmonic nanotorch: pushing plasmon-enhanced fluorescence for applications in single-molecule enzymology

    (Defence 30 September 2020)

    Matěj Horácek

    A plasmon ruler to probe conformational transitions of single molecules in real-time

    (Defence 12 June 2020)

    Max Scheepers

    Inter-particle biomolecular reactivity: how aggregation rates and selectivity are influenced by charge, surface crowders and multivalent interactions

    (Defence: 23 January 2020)

    Natalia Feiner Gracia

    Reaching the tumour: nanoscopy study of nanoparticles in the biological environment

    (Defence: 19 December 2019)

    Christian Moerland

    Torque on magnetic particles for biomedical applications

    (Defence: 7 November 2016)

    Fabiola Azucena Gutierrez Mejia

    Proteins with a Twist: Torsion Profiling of Proteins at the Single Molecule Level

    (Defence: 31 October 2018)

    Roland van Vliembergen

    Optical Scattering of Rotating Dimers for Biosensing Applications

    (Defence: 19 April 2017)

    Emiel Visser

    Biosensing Based on Tethered Particle Motion

    (Defence: 28 September 2016)

    Stefano Cappelli

    Magnetic Particles at Fluid-Fluid Interfaces: Microrheology, Interaction and Wetting

    Video on Plasmonic Biosensing using Metal Nanoparticles

    Metal nanoparticles provide the possibility to detect single molecules without the need for labeling, enabling the direct detection of non-absorbing species [1]. A molecule that binds to receptors on the surface of a particle induces a change in the local refractive index that in turn results in a change of color due to a shift of the plasmon resonance [2,3]. This animation illustrates the real-time detection of plasmon shifts induced by molecules binding to functionalized single gold nanorods. The plasmon shifts are measured by monitoring scattering intensities of many particles simultaneously and in real-time [4].