Quantify molecular processes with single molecule resolution
The MBx group creates concepts in the field of molecular biosensing with diagnostic and therapeutic healthcare perspectives. Combining nanotechnology, molecular engineering and single molecule imaging technologies we aim to measure with ultimate sensitivity biomolecules implicated in a variety of diseases, such as cancer, immunology, and cardiology.Read more
The Molecular Plasmonics group develops nanophotonic and plasmonic approaches for single-molecule detection using a single particle−single...
Biosensing by Particle Mobility
Nanoscopy for Nanomedicine
The development of nanostructured materials to achieve innovation in healthcare, i.e. nanomedicine, is one of the great challenges in...
Former research areas
Work with us!
Building a better future for our global society? Join our research team and be part of the thriving community at Eindhoven University of Technology.
We are continuously looking for enthusiastic and motivated students and postdocs. If you would like to work in a great environment at TU/e, please contact one of the staff members for more information.
Meet some of our Researchers
Arthur de Jong
Leo van Ijzendoorn
Laura van Smeden
Our most recent peer reviewed publications
Precision and accuracy of receptor quantification on synthetic and biological surfaces using DNA-PAINTACS Sensors (2023)
Single-Particle Functionality Imaging of Antibody-Conjugated Nanoparticles in Complex MediaACS Applied Bio Materials (2023)
Spectrally PAINTing a Single Chain Polymeric Nanoparticle at Super-ResolutionJournal of the American Chemical Society (2022)
Enabling Spectrally Resolved Single-Molecule Localization Microscopy at High Emitter DensitiesNano Letters (2022)
Reversible Immunosensor for the Continuous Monitoring of Cortisol in Blood Plasma Sampled with MicrodialysisACS Sensors (2022)
Check out all our courses
The research group Molecular Biosensing for Medical Diagnostics provides courses and projects in the bachelor's and master's programs of the departments of Biomedical Engineering and Applied Physics. Furthermore, we offer a broad range of projects for students to work on in the research group.
Molecular Mapping of Nanoparticle Targeting: A Super-Resolved Journey
Biofunctionalization strategies for continuous monitoring biosensors
Continuous biomolecular sensing with single-molecule resolution: Explorations of bioanalytical functionalities
Correlative microscopic characterization of nanoscale assemblies at interfaces
A plasmonic nanotorch: pushing plasmon-enhanced fluorescence for applications in single-molecule enzymology
A plasmon ruler to probe conformational transitions of single molecules in real-time
Inter-particle biomolecular reactivity: how aggregation rates and selectivity are influenced by charge, surface crowders and multivalent interactions
Natalia Feiner Gracia
Reaching the tumour: nanoscopy study of nanoparticles in the biological environment
Torque on magnetic particles for biomedical applications
Fabiola Azucena Gutierrez Mejia
Proteins with a Twist: Torsion Profiling of Proteins at the Single Molecule Level
Roland van Vliembergen
Optical Scattering of Rotating Dimers for Biosensing Applications
Biosensing Based on Tethered Particle Motion
Magnetic Particles at Fluid-Fluid Interfaces: Microrheology, Interaction and Wetting
Alexander van Reenen
Dynamic Magnetic Particle Actuation for Integrated Lab-on-Chip Biosensing
Mechanics of the Contact Interface between Cells and Functionalized Surfaces
Video on Plasmonic Biosensing using Metal Nanoparticles
Metal nanoparticles provide the possibility to detect single molecules without the need for labeling, enabling the direct detection of non-absorbing species . A molecule that binds to receptors on the surface of a particle induces a change in the local refractive index that in turn results in a change of color due to a shift of the plasmon resonance [2,3]. This animation illustrates the real-time detection of plasmon shifts induced by molecules binding to functionalized single gold nanorods. The plasmon shifts are measured by monitoring scattering intensities of many particles simultaneously and in real-time .