Super-resolution study of nanomaterials structure and properties

The understanding of the physicochemical properties of nanoparticles is key towards the painting of structure-activity relations. However, this is hampered by the limitations of many characterization techniques used that often can measure only a single property at the time and at the ensemble level, i.e. averaging out all the nanoparticles missing particle-to-particle heterogeneity. Here we aim to use single-molecule localization super-resolution imaging (STORM, DNA-PAINT) to map multiple parameters at the single-particle level. These multiparametric analysis can provide a more detailed characterization of material properties and their heterogeneity guiding the rational synthesis of more controlled and defined materials.