Department of Biomedical Engineering

Orthopaedic Biomechanics

We explore and develop (regenerative) treatment strategies for orthopaedic injuries and disorders based on a thorough understanding of musculoskeletal tissue mechanobiology and biomechanical function.

Novel treatment strategies for an ever-active ageing population

Human cells produce, maintain and adapt musculoskeletal tissues such as bone and cartilage as a response to their biophysical environment, both in health and disease. In our ever-aging population, orthopaedic injuries and degenerative diseases have become more prevalent, with an increasing socioeconomic impact. Current treatment methods with purely synthetic devices may be limited in view of the increasing longevity and high level of activity of modern day humans. The Orthopaedic Biomechanics research group combines engineering and biology to expand our understanding of musculoskeletal tissues and to develop (regenerative) treatment strategies. These are currently applied to bone, articular cartilage, intervertebral disc and tendons/ligaments.

Research Lines

Research Line of Orthopaedic Biomechanics

Bone Tissue Engineering

The goal is to understand cell-mediated processes (physiological, pathological, regenerative) in bones by means of bioengineering…

Research Line of Orthopaedic Biomechanics

Bone Function and Structure

The main function of bone is to provide strength and stiffness to the musculoskeletal system.

Research Line of Orthopaedic Biomechanics

Osteoarthritis and Cartilage Tissue Engineering

Degenerative joint disease, another common musculoskeletal disease, is believed to be a result of disturbed balance between strength of…

Research Line of Orthopaedic Biomechanics

Intervertebral Disc

Low back pain is one of the most common causes of disability for individuals of working age in developed countries.

Research Line of Orthopaedic Biomechanics

Tendon and Ligament Mechanobiology

Develop strategies to treat tendons and ligaments gone wrong.

Related Events

  • 21 Mar

    Graduate School Event 2023

    March 21, 2023 3:00 PM / TU/e campus

  • 21 Mar
    Monitoring the critical newborn

    PhD defense Gabriele Varisco

    March 21, 2023 / TU/e Campus

  • 22 Mar
    Quantification of Nanomaterials with Spectrally-Resolved Super-Resolution Microscopy

    PhD defense Emmanouil Archontakis

    March 22, 2023 / TU/e Campus

  • 23 Mar
    Can we end fossil fuels?

    EnergyDays

    Join us for a debate on the future of fossil fuels chaired by Heleen de Coninck.

  • 23 Mar
    Understanding the divergence of prostate cancer genomics among patients

    PhD defense

    March 23, 2023 / TU/e Campus

  • 23 Mar
    Discrete-to-continuum limits of evolutionary equations via generalized gradient flows

    PhD defense Anastasiia Hraivoronska

    March 23, 2023 / TU/e Campus

  • 23 Mar
    Quantum Crystals or Selective-area heteroepitaxy platform for IV-Te nanowires

    PhD defense Alexander Gerardus Schellingerhout

    March 23, 2023 / TU/e Campus

  • 24 Mar
    [Translate to English:]

    Inaugural lecture prof.dr. Michel Chaudron

    March 24, 2023 4:00 PM / Blauwe Zaal

  • 24 Mar
    28 Mar
    March 13, 2023
    Departmental Webinar series for TU/e Faculty and Staff

    JoVE in Teaching and Practical Training

    March 24, 2023 / Online

  • 24 Mar
    Membrane‐assisted direct dehydrogenation technology for light olefins production

    PhD defense Camilla Brencio

    March 24, 2023 / TU/e Campus

  • 24 Mar
    Unraveling the physics of the hygro-expansion of paper

    PhD defense Nicolaas Hendrikus Vonk

    March 24, 2023 / TU/e Campus

  • 27 Mar
    AI for the real world

    Women in Data Science Eindhoven 2023

    After a succesfull in-person event last year, Women in Data Science (WiDS) Eindhoven will return on Monday 27 March 2023.

    • ERC Proof of Concept grant for screening drug effects on bone ex vivo

    Dr. Sandra Hofmann has been awarded an ERC Proof of Concept grant for her project ‘An ex vivo platform to screen drug effects on bone’. In collaboration with TU/e Innovation Space, LifeTec Group, and OsteoPharma, this BoneScreen platform will be validated for its efficacy in screening the effect of drugs on bone cells longitudinally.

    NWO Demonstrator grant for ‘ultrACLean’

    Dr. Jasper Foolen, together with Prof. Jan de Boer, was awarded an NWO Demonstrator grant for the project: “ultrACLean: A novel decellularized off-the-shelf human graft for improved anterior cruciate ligament reconstruction”.

    • Read more
    • Other news of the department of Biomedical Engineering

    International research project iPSpine

    Chronic lower back pain (LBP) is the leading cause of disability and morbidity worldwide. More than 700 million people globally of all ages are affected each year. LBP is a major cause of reduced activity and work absence, and imposes an economic burden of nearly ~€240 billion every year in the EU. iPSpine aims to investigate and develop a new therapy for LBP using induced pluripotent stem cells (iPSCs). The project will develop an advanced therapy using iPS-technology and smart biomaterials that will be translated from laboratory models into a clinically relevant animal model. By the end of the project, the therapy should be ready for advancement to the first human clinical trial.

    Meet some of our Researchers

    University Lecturer

    Chris Arts

    Former Doctoral Candidate

    Celien Jacobs

    Associate Professor

    Rob Janssen

    Associate Professor

    René van Donkelaar

    Assistant Professor

    Jasper Foolen

    Assistant Professor

    Wouter Wilson

    Full Professor

    Keita Ito

    Doctoral Candidate

    Esther Cramer

    Postdoc

    Joeri Kok

    Associate Professor

    Bert van Rietbergen

    Doctoral Candidate

    Rienk Schuiringa

    Doctoral Candidate

    Michelle Vis

    Assistant Professor

    Linda Kock

    Doctoral Candidate

    Tara Schmitz

    Associate Professor

    Sandra Hofmann

    Former Doctoral Candidate

    Bregje de Wildt

    University Researcher

    Paula Vena

    Doctoral Candidate

    Melissa Bevers

    Assistant Professor

    Miguel Dias Castilho

    Former Doctoral Candidate

    Alicia Damen

    Doctoral Candidate

    Sana Ansari

    Recent Publications

    Our most recent peer reviewed publications

    Student opportunities

    The Orthopaedic Biomechanics group provides courses and projects in the bachelor's and master's program.

    Partners and Cooperation

    The Orthopaedic Biomechanics groups collaborates with different partners in academia and industry. Collaborations are within the Netherlands, but also go beyond borders.

    Contact