Department of Biomedical Engineering

Orthopaedic Biomechanics

We explore and develop (regenerative) treatment strategies for orthopaedic injuries and disorders based on a thorough understanding of musculoskeletal tissue mechanobiology and biomechanical function.

Novel treatment strategies for an ever-active ageing population

Human cells produce, maintain and adapt musculoskeletal tissues such as bone and cartilage as a response to their biophysical environment, both in health and disease. In our ever-aging population, orthopaedic injuries and degenerative diseases have become more prevalent, with an increasing socioeconomic impact. Current treatment methods with purely synthetic devices may be limited in view of the increasing longevity and high level of activity of modern day humans. The Orthopaedic Biomechanics research group combines engineering and biology to expand our understanding of musculoskeletal tissues and to develop (regenerative) treatment strategies. These are currently applied to bone, articular cartilage, intervertebral disc and tendons/ligaments.

Research Lines

ERC Proof of Concept grant for screening drug effects on bone ex vivo

Dr. Sandra Hofmann has been awarded an ERC Proof of Concept grant for her project ‘An ex vivo platform to screen drug effects on bone’. In collaboration with TU/e Innovation Space, LifeTec Group, and OsteoPharma, this BoneScreen platform will be validated for its efficacy in screening the effect of drugs on bone cells longitudinally.

NWO Demonstrator grant for ‘ultrACLean’

Dr. Jasper Foolen, together with Prof. Jan de Boer, was awarded an NWO Demonstrator grant for the project: “ultrACLean: A novel decellularized off-the-shelf human graft for improved anterior cruciate ligament reconstruction”.

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International research project iPSpine

Chronic lower back pain (LBP) is the leading cause of disability and morbidity worldwide. More than 700 million people globally of all ages are affected each year. LBP is a major cause of reduced activity and work absence, and imposes an economic burden of nearly ~€240 billion every year in the EU. iPSpine aims to investigate and develop a new therapy for LBP using induced pluripotent stem cells (iPSCs). The project will develop an advanced therapy using iPS-technology and smart biomaterials that will be translated from laboratory models into a clinically relevant animal model. By the end of the project, the therapy should be ready for advancement to the first human clinical trial.

Meet some of our Researchers

Student opportunities

The Orthopaedic Biomechanics group provides courses and projects in the bachelor's and master's program.

Partners and Cooperation

The Orthopaedic Biomechanics groups collaborates with different partners in academia and industry. Collaborations are within the Netherlands, but also go beyond borders.