Novel treatment strategies for an ever-active ageing population
Human cells produce, maintain and adapt musculoskeletal tissues such as bone and cartilage as a response to their biophysical environment, both in health and disease. In our ever-aging population, orthopaedic injuries and degenerative diseases have become more prevalent, with an increasing socioeconomic impact. Current treatment methods with purely synthetic devices may be limited in view of the increasing longevity and high level of activity of modern day humans. The Orthopaedic Biomechanics research group combines engineering and biology to expand our understanding of musculoskeletal tissues and to develop (regenerative) treatment strategies. These are currently applied to bone, articular cartilage, intervertebral disc and tendons/ligaments.
Bone Tissue Engineering
The goal is to understand cell-mediated processes (physiological, pathological, regenerative) in bones by means of bioengineering...
Bone Function and Structure
The main function of bone is to provide strength and stiffness to the musculoskeletal system.
Osteoarthritis and Cartilage Tissue Engineering
Degenerative joint disease, another common musculoskeletal disease, is believed to be a result of disturbed balance between strength of...
Low back pain is one of the most common causes of disability for individuals of working age in developed countries.
Tendon and Ligament Mechanobiology
Develop strategies to treat tendons and ligaments gone wrong.
Meet some of our Researchers
Bregje de Wildt
Bert van Rietbergen
René van Donkelaar
Miguel Dias Castilho
Our most recent peer reviewed publications
Tissue-specific melt electrowritten polymeric scaffolds for coordinated regeneration of soft and hard periodontal tissuesBioactive Materials (2023)
Evaluating material-driven regeneration in a tissue engineered human in vitro bone defect modelBone (2023)
Towards a load bearing hydrogel: A proof of principle in the use of osmotic pressure for biomimetic cartilage constructsJournal of the Mechanical Behavior of Biomedical Materials (2023)
A decellularized and sterilized human meniscus allograft for off-the-shelf meniscus replacementJournal of Experimental Orthopaedics (2022)
A tailored intervention does not reduce low value MRI’s and arthroscopies in degenerative knee disease when the secular time trend is taken into accountKnee Surgery, Sports Traumatology, Arthroscopy (2022)