Novel treatment strategies for an ever-active ageing population
Human cells produce, maintain and adapt musculoskeletal tissues such as bone and cartilage as a response to their biophysical environment, both in health and disease. In our ever-aging population, orthopaedic injuries and degenerative diseases have become more prevalent, with an increasing socioeconomic impact. Current treatment methods with purely synthetic devices may be limited in view of the increasing longevity and high level of activity of modern day humans. The Orthopaedic Biomechanics research group combines engineering and biology to expand our understanding of musculoskeletal tissues and to develop (regenerative) treatment strategies. These are currently applied to bone, articular cartilage, intervertebral disc and tendons/ligaments.
Bone Tissue Engineering
The goal is to develop a human cell-based, functional, 3D in vitro model of bone.
Bone Structure and Function
The main function of bone is to provide strength and stiffness to the musculoskeletal system.
Degenerative joint disease, another common musculoskeletal disease, is believed to be a result of disturbed balance between strength of...
Low back pain is one of the most common causes of disability for individuals of working age in developed countries.
Tendons and Ligaments
Develop strategies to treat tendons and ligaments gone wrong.
Meet some of our Researchers
René van Donkelaar
Marc van Vijven
Sandra Hofmann Boss
Bert van Rietbergen
Our most recent peer reviewed publications
Combined enzymatic degradation of proteoglycans and collagen significantly alters intratissue strains in articular cartilage during cyclic compressionJournal of the Mechanical Behavior of Biomedical Materials (2019)
Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture regionBone (2019)
Spatiotemporal material functionalization via competitive supramolecular complexation of avidin and biotin analogsNature Communications (2019)
Bi-layered micro-fibre reinforced hydrogels for articular cartilage regenerationActa Biomaterialia (2019)
The association between prevalent vertebral fractures and bone quality of the distal radius and distal tibia as measured with HR-pQCT in postmenopausal women with a recent non-vertebral fracture at the Fracture Liaison ServiceOsteoporosis International (2019)