Novel treatment strategies for an ever-active ageing population
Human cells produce, maintain and adapt musculoskeletal tissues such as bone and cartilage as a response to their biophysical environment, both in health and disease. In our ever-aging population, orthopaedic injuries and degenerative diseases have become more prevalent, with an increasing socioeconomic impact. Current treatment methods with purely synthetic devices may be limited in view of the increasing longevity and high level of activity of modern day humans. The Orthopaedic Biomechanics research group combines engineering and biology to expand our understanding of musculoskeletal tissues and to develop (regenerative) treatment strategies. These are currently applied to bone, articular cartilage, intervertebral disc and tendons/ligaments.
Bone Tissue Engineering
The goal is to develop a human cell-based, functional, 3D in vitro model of bone.
Bone Structure and Function
The main function of bone is to provide strength and stiffness to the musculoskeletal system.
Degenerative joint disease, another common musculoskeletal disease, is believed to be a result of disturbed balance between strength of...
Low back pain is one of the most common causes of disability for individuals of working age in developed countries.
Tendons and Ligaments
Develop strategies to treat tendons and ligaments gone wrong.
Meet some of our Researchers
René van Donkelaar
Marc van Vijven
Sandra Hofmann Boss
Bert van Rietbergen
Our most recent peer reviewed publications
Prospective follow-Up of cortical interruptions, bone density, and micro-structure detected on HR-pQCTCalcified Tissue International (2019)
Notochordal cell matrix as a therapeutic agent for intervertebral disc regenerationTissue Engineering - Part A (2019)
Cardiomyocyte contractile force changes in response to AGRWE detected by AFMMicro and Nano Letters (2019)
Implementation of a semiautomatic method to design patient-specific instruments for corrective osteotomy of the radiusInternational Journal of Computer Assisted Radiology and Surgery (2019)
Hypotonicity differentially affects inflammatory marker production by nucleus pulposus tissue in simulated disc degeneration versus herniationJournal of Orthopaedic Research (2019)