Beyond the already impressive functional diversity of natural proteins
Our group operates at the interface of chemical biology and synthetic biology. Combining protein engineering and DNA nanotechnology, we develop intelligent biomolecular sensors and switches for applications in intracellular imaging, optogenetics, point-of-care diagnostics and antibody-based therapies. An important research theme is to develop generic engineering concepts for the development of protein-based switches, which include fluorescent sensors for intracellular imaging of metal ions, photo-switchable proteins, and protein-based sensors for antibody detection and actuation. We have an active policy of sharing our protein building blocks by depositing our plasmids to AddGene and promote their use by writing dedicated protocols and tutorial reviews. In education, our main goal is to train bachelor, masters and PhD students to become creative biomolecular engineers and independent critical scientists.
Research Lines
Meet some of our Researchers
Recent Publications
Our most recent peer reviewed publications
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Single-Particle Functionality Imaging of Antibody-Conjugated Nanoparticles in Complex Media
ACS Applied Bio Materials (2023) -
Bioluminescence Goes Dark
ACS Sensors (2022) -
Modular mixing of benzene-1,3,5-tricarboxamide supramolecular hydrogelators allows tunable biomimetic hydrogels for control of cell aggregation in 3D
Biomaterials Science (2022) -
iFLinkC-X
Bioconjugate Chemistry (2022) -
Switchable Control of Scaffold Protein Activity via Engineered Phosphoregulated Autoinhibition
ACS Synthetic Biology (2022)
Student opportunities
The Protein Engineering group provides courses and projects in the bachelor's and master's program.
Contact
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Visiting address
Secretary Tanja Vermaas - VerhaagGroene Loper, Building 14, Helix (room STO 3.39)5612 AP EindhovenNetherlands -
Visiting address
Secretary Tanja Vermaas - VerhaagGroene Loper, Building 14, Helix (room STO 3.39)5612 AP EindhovenNetherlands -
Postal address
Department of Biomedical EngineeringP.O. Box 5135600 MB EindhovenNetherlands -
Postal address
Department of Biomedical EngineeringP.O. Box 5135600 MB EindhovenNetherlands -
Secretarya.m.j.verhaag@ tue.nl