Soft Tissue Engineering and Mechanobiology
At STEM we aim to understand and predict how mechanobiological factors influence soft tissue growth, remodelling, damage, and repair. We use this knowledge to (re)build soft tissues and organs within the human body, and to find ways to prevent mechanobiology related soft tissue degeneration.
Modelling and experimentation at length scales from molecule to man
While performing our research at the forefront of soft tissue biomechanics, mechanobiology, and the engineering of living soft biological tissues and organs, we strive to provide a stimulating educational environment for graduate and post-graduate students. Our research is multi-disciplinary at heart, combining concepts from molecular, cell and tissue biology, (patho)physiology, immunology, biomechanics, physics, engineering, and materials science. To translate our fundamental knowledge to (bio)medical applications we actively collaborate with clinical partners, industry, and patient organizations.
Read moreResearch Lines
Meet some of our Researchers
News
Recent Publications
Our most recent peer reviewed publications
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Sandra Loerakker,Jay D. Humphrey
Computer Model-Driven Design in Cardiovascular Regenerative Medicine
Annals of Biomedical Engineering (2023) -
Elana M. Meijer,Suzanne E. Koch,Renee G.C. Maas,Ihsan Chrifi,Paul J. Besseling,Jan Willem Buikema,Carlijn V.C. Bouten,Marianne C. Verhaar,Anthal I.P.M. Smits,Caroline Cheng
3D Human iPSC Blood Vessel Organoids as a Source of Flow-Adaptive Vascular Cells for Creating a Human-Relevant 3D-Scaffold Based Macrovessel Model
Advanced Biology (2023) -
Dylan Mostert,Leda Klouda,Robert Passier,Marie-Jose Goumans,Nicholas A. Kurniawan,Carlijn V.C. Bouten
Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblasts
APL Bioengineering (2022) -
Anthal I.P.M. Smits,Laura Iop,Adrian H. Chester
Editorial: Vascular and valvular tissue engineering: Treating and modeling vasculopathies and valvulopathies
Frontiers in Cardiovascular Medicine (2022) -
Yao Meng,Sami Sanlidag,Sacha A. Jensen,Sean A. Burnap,Weston B. Struwe,Andreas H. Larsen,Xinyi Feng,Shruti Mittal,Mark S.P. Sansom,Cecilia Sahlgren
An N-glycan on the C2 domain of JAGGED1 is important for Notch activation
Science Signaling (2022)
Some of our research programs
Research Center for Materials-Driven Regeneration (MDR)
The Research Center for Materials-Driven Regeneration (MDR) is a partnership between Eindhoven University of Technology, Maastricht University and Utrecht University, University Medical Center Utrecht and the Hubrecht Institute. This consortium was brought together to advance tissue and organ regeneration approaches with the use of instructive biomaterials. The interdisciplinary team of researchers within the MDR consortium aims to focus on the research and development of new, intelligent materials that stimulate the regeneration of damaged or diseased tissues and organs.
PhD Research Projects
Tissue Engineering and Regeneration
In this application area we focus on the engineering and regeneration of load bearing soft tissues, aimed at either the replacement of diseased or malformed tissues, or the development of well-defined in-vitro model systems of tissue growth, adaptation, regeneration and degeneration. Tissues of principle interest are heart valves and small diameter arteries, while new research lines concentrate on biomaterial-driven regeneration of organ functions (heart, kidney, cornea).
Labs and Facilities
State-of-the-art technologies and platforms to support the STEM researchers and students are available in the Cell and Tissue Engineering lab. This is a shared research facility that combines standard cell and tissue culture technologies with molecular/cell/tissue analysis, cell and tissue mechanical characterization, cell transfection, life imaging, in house developed bioreactors and micro-tissue platforms, and scaffold manufacturing (spinning, printing) and testing technologies.
In addition, the group houses a fully equipped microscopy facility with advanced fluorescent microscopes and dedicated confocal microscopy set-ups for on-line and prolonged monitoring of living cells and tissue. Through its collaborations within the Materials Technology (MaTe) Institute and with the Institute for Complex Molecular Systems (ICMS), the group has access to the laboratory for Biomechanics, the Materials Engineering facility, the Microfabrication Lab, and the Immuno-engineering facility.
Contact
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Postal address
P.O. Box 513Department of Biomedical Engineering Eindhoven University of Technology5600 MB EindhovenNetherlands -
Visiting address
Building 15, Gemini-South (room 4.115) Groene LoperEindhoven University of Technology5612 AZ EindhovenNetherlands -
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