Modelling and experimentation at length scales from molecule to man
While performing our research at the forefront of soft tissue biomechanics, mechanobiology, and the engineering of living soft biological tissues and organs, we strive to provide a stimulating educational environment for graduate and post-graduate students. Our research is multi-disciplinary at heart, combining concepts from molecular, cell and tissue biology, (patho)physiology, immunology, biomechanics, physics, engineering, and materials science. To translate our fundamental knowledge to (bio)medical applications we actively collaborate with clinical partners, industry, and patient organizations.Read more
We investigate how living cells shape and adapt their own environment in order to rationally design regenerative implants for the heart.
Form and function of tissues emerge from the synergy and not the extension of the mechanobiological properties of their single cells.
Modeling in Mechanobiology
Computational modeling for understanding and predicting tissue regeneration.
Understanding and harnessing the multiscale biophysical principles of cell–matrix interactions in tissue regeneration
Biomechanics of Soft Tissue
Modulating the immune system to induce tissue regeneration
Cell Signaling in Tissue Formation and Malformation
Cell fate decisions in complex environments
Meet some of our Researchers
Daisy van der Schaft
Our most recent peer reviewed publications
Computer Model-Driven Design in Cardiovascular Regenerative MedicineAnnals of Biomedical Engineering (2023)
3D Human iPSC Blood Vessel Organoids as a Source of Flow-Adaptive Vascular Cells for Creating a Human-Relevant 3D-Scaffold Based Macrovessel ModelAdvanced Biology (2023)
Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblastsAPL Bioengineering (2022)
Editorial: Vascular and valvular tissue engineering: Treating and modeling vasculopathies and valvulopathiesFrontiers in Cardiovascular Medicine (2022)
An N-glycan on the C2 domain of JAGGED1 is important for Notch activationScience Signaling (2022)
PhD Research Projects
Guiding renal epithelial cells to controlled tubule formation; the influence of mechanics
Towards patient-specific material-driven in situ cardiovascular regeneration: The influence of estrogen
Guiding keratocyte cell alignment and matrix organization through contact guidance
Manipulation of angiogenesis by using the Notch signaling pathway as an engineering tool
Can we restore structural cardiac organization?
Microfluidic mechanical bioinfluence on function of “kidney-on-chip”
Characterization and modulation of the immune response in in situ cardiovascular tissue engineering
In situ cardiovascular tissue engineering: investigating the initiation & early tissue formation
Guiding cell and matrix organization by scaffold fiber curvature
In this project we will investigate how cells can sense the scaffold fiber curvature and orientation. Furthermore we will explore how we can...
Notch signaling in cardiovascular tissue
In this PhD project we would like to understand the relationship between Notch signaling, hemodynamic forces and cardiovascular tissue...
Non-thrombogenicity in in-situ tissue engineered vascular access grafts
The ideal non-thrombogenic structure is the endogenous endothelium. Therefore we aim to create a luminal side of the graft that allows for...
Tissue homeostasis in in-situ tissue engineered vascular access grafts
To systematically investigate the relative contribution of graft anisotropy and graft degradation to tissue remodeling and architecture, a...
Supramolecular biomaterials in kidney regeneration and replacement strategies
In the current research we aim at resolving the interactions of the cell with the bioactive supramolecular biomaterial at a microscopic and...
Guiding the immune response in in situ tissue engineered vascular access grafts
The InSiTeVx project aims to develop an off-the-shelf, synthetic, biodegradable, AV-graft that will develop in vivo into a living,...
The role of vascular hemodynamic loading on the identified link between vimentin and notch signalling in vascular cells
The aim of this project is to understand the integration between the mechanics and cell-cell signalling in vascular tissue architecture and...
A novel microfluidic breast cancer model to study the relation between the Notch pathway and mechanotransduction in metastasis
In order to overcome these challenges, we aim to develop a novel breast cancer model that incorporates the relevant properties of the...
Postal addressP.O. Box 513Department of Biomedical Engineering Eindhoven University of Technology5600 MB EindhovenNetherlands
Visiting addressBuilding 15, Gemini-South (room 4.115) Groene LoperEindhoven University of Technology5612 AZ EindhovenNetherlands