Growth and remodeling are key processes in healthy tissue development as well as tissue adaptation in response to changes in demands. A mechanistic understanding of growth and remodeling is essential to force breakthroughs in the field of regenerative medicine, and accelerate clinical translation. In our research, we focus on understanding how mechanical stimuli regulate growth and remodeling, with the aim to apply those insights to improve regenerative therapies. Computational modeling plays a central role in our research, although a strong coupling with experimental research is always preferred. With our models, we integrate soft tissue biomechanics and mechanobiological processes at different length and time scales, in order to improve our understanding of experimental outcomes, predict long-term tissue adaptation, and use that predictive capacity to contribute to the design of biomaterials for regenerative therapies.