Research Line of Soft Tissue Engineering and Mechanobiology

Synthetic Morphogenesis

Form and function of tissues emerge from the synergy and not the extension of the mechanobiological properties of their single cells.

Controlling the biological and mechanical behaviour of cells at the molecular level is a central axiom of bioengineering in its pursuit of tissue and organ regeneration. However, steering living-cell aggregates towards predesigned tissue architectures requires the concertation of factors such as the signalling, shape, force, adhesion and motility of single cells at length- and time-scales still largely unknown. Moreover, increasing evidence points out that the emergence of collective behaviour in cellular assemblies such as tissues is governed by mesoscale physical principles that may also instruct cell biological function in an independent manner. Yet these principles at the tissue scale cannot be predicted from biochemical principles at the single-cell scale. Our research aims at understanding the role of cell mechanics in tissue (mal)formation by harnessing the mesoscale mechanical strategies that in vivo and in vitro cell collectives adopt to determine tissue form and function. By so doing, we wish to provide bioengineers with a modern swatch of fundamental principles that can be utilised to master synthetic morphogenesis and tissue design for regenerative and therapeutic purposes.