Bachelor End Project of Soft Tissue Engineering and Mechanobiology

MRI based 3D finite element modelling of deep tissue injury


Mechanical loading can induce a localised degradation of soft tissue, known as a pressure ulcer. If these ulcers originate at the skin surface they are easily detectable resulting in appropriate treatment. However, ulcers known as deep tissue injury are difficult to diagnose since they originate in deeper tissues. Currently, a lot has to be learned about the aetiology of these ulcers. 

Previously, a mechanical load was applied to the tibialis anterior muscle of rats and monitored with magnetic resonance imaging (MRI). MRI based finite element analysis was performed and compared to the damage obtained from MRI. This showed that damage occurs above a certain threshold of loading. However, this analysis was only performed directly underneath the indenter. New results show that physiological changes are not limited to this region.

The previous developed finite element model was extended to 3D. The goal of this project is to test the effect of experimental conditions.