Eline Sijbesma-Van Dun
Department / Institute
Group
RESEARCH PROFILE
Eline Sijbesma is a PhD student in the Chemical Biology research group of professor Luc Brunsveld. Her current research focusses on the exploration of fragment-based drug discovery to identify small molecule stabilizers, that act as 'molecular glues' enhancing interactions between proteins. This approach is inspired by nature - which makes extensive use of the stabilization of protein complexes - and aims to provide new modalities to expand the druggable proteome, address therapeutic resistance and tackle challenging diseases.
Interactions between proteins are at the core of all biological processes yet inherently challenging drug targets. This inspires us to employ unexplored approaches at the forefronts of drug discovery.
ACADEMIC BACKGROUND
Eline Sijbesma first joined the Chemical Biology group as an undergraduate student. During her MSc graduation project she worked on elucidating the binding mode of natural compound Estrogen Receptor modulators. Part of this research was performed in the group of dr. Wilbert Zwart at the Netherlands Cancer Institute (NKI-AVL). She then joined the Small Molecule Discovery Center (SMDC) in the group of prof. Michelle Arkin, PhD at the University of California in San Francisco (UCSF) where she initiated a fragment-based drug discovery project that explores protein-protein interactions as novel drug targets. For this research internship she was awarded a travel grant from the Nora Baart Foundation (NVBMB) and a Scholarship by the Dr Hendrik Muller’s Fund. Eline obtained her Master of Science degree cum laude in 2015 and started her PhD under supervision of prof. dr. ir. Luc Brunsveld and dr. Christian Ottmann.
Recent Publications
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Emira J. Visser,Priyadarshini Jaishankar,Eline Sijbesma,Marloes A.M. Pennings,Edmee M.F. Vandenboorn,Xavier Guillory,R. Jeffrey Neitz,John Morrow,Shubhankar Dutta,Adam R. Renslo
From Tethered to Freestanding Stabilizers of 14-3-3 Protein-Protein Interactions through Fragment Linking
Angewandte Chemie - International Edition (2023) -
Bente A. Somsen,Eline Sijbesma,Seppe Leysen,Karolina Honzejkova,Emira J. Visser,Peter J. Cossar,Tomáš Obšil,Luc Brunsveld,Christian Ottmann
Molecular basis and dual ligand regulation of tetrameric Estrogen Receptor α/14-3-3ζ protein complex
Journal of Biological Chemistry (2023) -
Dyana N. Kenanova,Emira J. Visser,Johanna M. Virta,Eline Sijbesma,Federica Centorrino,Holly R. Vickery,Mengqi Zhong,R. Jeffrey Neitz,Luc Brunsveld,Christian Ottmann
A Systematic Approach to the Discovery of Protein-Protein Interaction Stabilizers
ACS Central Science (2023) -
Eline Sijbesma,Kenneth K. Hallenbeck,Sebastian A. Andrei,J.M.C. Adriaans,Lucas Brunsveld,M.R Arkin,Christian Ottmann
Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers
ACS Medicinal Chemistry Letters (2021) -
Eline Sijbesma,Bente A Somsen,Galen P Miley,Iris A Leijten-van de Gevel,Luc Brunsveld,Michelle R Arkin,Christian Ottmann
Fluorescence Anisotropy-Based Tethering for Discovery of Protein-Protein Interaction Stabilizers
ACS Chemical Biology (2020)
Ancillary Activities
No ancillary activities