Esther Cramer is a doctoral candidate (PhD) in the Laboratory of Materials and Interface Chemistry (SMG) under the supervision of Prof. Dr. Nico Sommerdijk. Her current research focusses on understanding the mechanisms involved in collagen organization and mineralization of bone tissue. To mimic the native microenvironment in bone, a microfluidic device will be developed that can induce cellular differentiation and collagen synthesis. This model should allow to analyze the dynamic processes in bone formation under live and cryogenic conditions, using fluorescence and electron microscopy techniques. This multidisciplinary project covers a broad range of topics, such as mechanobiology, collagen organization and mineralization, bone-on-a-chip technology and electron microscopy.
Esther Cramer studied Biomedical Engineering at Eindhoven University of Technology where she received her BSc degree in 2015. At the same university, she obtained her MSc degree in 2018 in the Orthopaedic Biomechanics research group of Keita Ito. During her graduation project supervised by Dr. Sandra Hofmann, she focused on promoting vascularization in bone tissue engineered constructs. As part of her MSc degree, she completed an internship at Prof. David Kaplan’s Lab at Tufts University in Boston working on 3D printing with silk fibroin for bone tissue engineering applications. In 2019, she joined the Laboratory of Materials and Interface chemistry as a PhD-student investigating collagen organization and mineralization in bone using a microfluidic device.
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