Esther Cramer
Department / Institute
Group
RESEARCH PROFILE
Esther Cramer is a doctoral candidate (PhD) in Orthopaedic Biomechanics (OPB) under the supervision of Prof. Dr. Keita Ito and Dr. Sandra Hofmann. Her current research focusses on the development of an ex vivo model to study bone remodeling. This addresses the problem of the poor correlation between in vitro experimental outcomes, which often lack the complexity of the natural bone environment, and in vivo results. Ex vivo cultures could provide a solution because they maintain cells in their native 3D environment. This multidisciplinary project covers a broad range of topics and techniques, such as tissue culture, bone remodeling, histology and microscopy, biomechanics as well as cell behavior and their interactions.
ACADEMIC BACKGROUND
Esther Cramer studied Biomedical Engineering at Eindhoven University of Technology where she received her BSc degree in 2015. At the same university, she obtained her MSc degree in 2018 in the Orthopaedic Biomechanics research group of Keita Ito. During her graduation project supervised by Dr. Sandra Hofmann, she focused on promoting vascularization in bone tissue engineered constructs. As part of her MSc degree, she completed an internship at Prof. David Kaplan’s Lab at Tufts University in Boston working on 3D printing with silk fibroin for bone tissue engineering applications. In 2019, she joined the Orthopaedic Biomechanics group as a PhD-student investigating bone remodeling using an ex vivo model.
Recent Publications
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Esther E.A. Cramer,Bregje W.M. de Wildt,Johannes G.E. Hendriks,Keita Ito,Sandra Hofmann
Integration of osteoclastogenesis through addition of PBMCs in human osteochondral explants cultured ex vivo
Bone (2024) -
Esther Elisabeth Agnes Cramer
Ex vivo bone explant cultures for evaluation of remodeling and bone substitutes
(2023) -
Bregje W.M. de Wildt,Esther E.A. Cramer,Annelieke S. Wentzel,Keita Ito,Sandra Hofmann
The Impact of Culture Variables on a 3D Human In Vitro Bone Remodeling Model
Advanced Healthcare Materials (2023) -
Celien A.M. Jacobs,Esther E.A. Cramer,Aylvin A. Dias,Harold Smelt,Sandra Hofmann,Keita Ito
Surface modifications to promote the osteoconductivity of ultra-high-molecular-weight-polyethylene fabrics for a novel biomimetic artificial disc prosthesis
Journal of Biomedical Materials Research, Part B: Applied Biomaterials (2023) -
Bregje W.M. de Wildt,Esther E.A. Cramer,Leanne S. de Silva,Keita Ito,Debby Gawlitta,Sandra Hofmann
Evaluating material-driven regeneration in a tissue engineered human in vitro bone defect model
Bone (2023)
Ancillary Activities
No ancillary activities