Katja Petkau - Milroy
Katja Petkau-Milroy is an assistant professor at the department of Biomedical Engineering within the research group of Biomedical Engineering headed by professor E.W. (Bert) Meijer. Her current research aims towards a deeper understanding of self-assembly and controlled drug release. The long term goal of nanomedicine is to deliver drugs which are only released in the diseased tissue in a controlled fashion. To achieve this, tailorable, reproducible, and highly controlled drug delivery systems are required. Generating drug delivery systems from ill-defined polydisperse (block-co-)polymers, the current status quo, might be one of the reasons for limited translation into the clinics. Nature, the ultimate source of inspiration, uses discrete and sequence controlled building blocks to generate highly complex and controlled macromolecular assemblies. In her research she aims to establish the effects dispersity and crystallinity upon self-assembly.
Katja Petkau-Milroy studied chemistry at the TU Dortmund (Germany) where she obtained her MSc degree in 2008, having performed a research project at the Max Planck Institute for Molecular Physiology (Dortmund, Germany). She then started her PhD research at Eindhoven University of Technology (TU/e, the Netherlands) with Prof. Luc Brunsveld of the Chemical Biology group. In 2012, she obtained her PhD with her thesis on the development of self-assembling auto-fluorescent amphiphiles as dynamic and modular tools for targeted imaging. After a short postdoc project at TU/e she started working in pharmaceutical R&D at Octoplus B.V (a Dr. Reddy’s subsidiary) in Leiden, on liposomal and microspheric generics for sustained drug release. Since 2016, she is a senior research fellow at the TU/e department of Biomedical Engineering in the group of Prof. E.W. (Bert) Meijer. There she leads research towards the development of controlled drug release using supramolecular polymers and self-assembling amphiphiles.
Consequences of dispersity on the self-assembly of ABA-Type amphiphilic block co-oligomersACS Macro Letters (2018)
Dynamic and bio-orthogonal protein assembly along a supramolecular polymerChemical Science (2013)
Supramolecular polymers as dynamic multicomponent cellular uptake carriersJournal of the American Chemical Society (2012)
Pre- and postfunctionalized self-assembled pi-conjugated fluorescent organic nanoparticles for dual targetingJournal of the American Chemical Society (2011)
Structure-activity relationship studies of miniproteins targeting the androgen receptor-coactivator interactionMedChemComm (2013)
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