Michelle Vis is a doctoral candidate (PhD) in Orthopaedic Biomechanics (OPB) under the supervision of Prof. Dr. Keita Ito and Dr. Sandra Hofmann. Her current research focusses on the development of a miniaturized in vitro model to study bone remodeling using human cells. In the future, such a model could be used to replace animal models for drug testing, mimicking a true human response. This multidisciplinary project covers a broad range of topics and techniques, such as tissue culture, bone remodeling, microfluidics, biomechanics, histology and microscopy, and cell interactions and behavior.
Michelle Vis studied Biomedical Engineering at Eindhoven University of Technology where she received her BSc degree in 2016. At the same university, she obtained her MSc degree in 2019 in the Orthopaedic Biomechanics research group of Keita Ito. During her graduation project supervised by Dr. Sandra Hofmann, she focused on promoting vascularization in bone tissue engineered constructs. As part of her MSc degree, she completed an internship at the Christchurch Regenerative Medicine and Tissue Engineering group (CReaTE) at Otago University in Christchurch, New Zealand. She worked on silk fibroin hydrogels for cartilage tissue engineering applications. In 2019, she joined the Orthopaedic Biomechanics group as a PhD-student investigating bone remodeling by creating in vitro mini bones.
Capturing Essential Physiological Aspects of Interacting Cartilage and Bone Tissue with Osteoarthritis Pathophysiology: A Human Osteochondral Unit-on-a-Chip ModelAdvanced Materials Technologies (2022)
Osteoblast-osteoclast co-culturesPLoS ONE (2021)
Matrix Vesicles: Role in Bone Mineralization and Potential Use as TherapeuticsPharmaceuticals (2021)
Impact of Culture Medium on Cellular Interactions in in vitro Co-culture SystemsFrontiers in Bioengineering and Biotechnology (2020)
Rapid Photocrosslinking of Silk Hydrogels with High Cell Density and Enhanced Shape FidelityAdvanced Healthcare Materials (2020)
No ancillary activities