Michelle Vis
Department / Institute
Group
RESEARCH PROFILE
Michelle Vis is a doctoral candidate (PhD) in Orthopaedic Biomechanics (OPB) under the supervision of Prof. Dr. Keita Ito and Dr. Sandra Hofmann. Her current research focusses on the development of a miniaturized in vitro model to study bone remodeling using human cells. In the future, such a model could be used to replace animal models for drug testing, mimicking a true human response. This multidisciplinary project covers a broad range of topics and techniques, such as tissue culture, bone remodeling, microfluidics, biomechanics, histology and microscopy, and cell interactions and behavior.
ACADEMIC BACKGROUND
Michelle Vis studied Biomedical Engineering at Eindhoven University of Technology where she received her BSc degree in 2016. At the same university, she obtained her MSc degree in 2019 in the Orthopaedic Biomechanics research group of Keita Ito. During her graduation project supervised by Dr. Sandra Hofmann, she focused on promoting vascularization in bone tissue engineered constructs. As part of her MSc degree, she completed an internship at the Christchurch Regenerative Medicine and Tissue Engineering group (CReaTE) at Otago University in Christchurch, New Zealand. She worked on silk fibroin hydrogels for cartilage tissue engineering applications. In 2019, she joined the Orthopaedic Biomechanics group as a PhD-student investigating bone remodeling by creating in vitro mini bones.
Recent Publications
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M.A.M. Vis,F. Zhao,H. Eslami Amirabadi,K. Ito,S. Hofmann
Osteogenesis and osteoclastogenesis on a chip
Bone (2023) -
Michelle Anna Maria Vis
Microenvironmental advancement and miniaturization of human in vitro bone models
(2023) -
Michelle A.M. Vis,Bregje W.M. de Wildt,Keita Ito,Sandra Hofmann
A dialysis medium refreshment cell culture set-up for an osteoblast-osteoclast coculture
Biotechnology and Bioengineering (2023) -
Margo Tuerlings,I. Boone,Hossein Eslami Amirabadi,Michelle A.M. Vis,Eka Suchiman,Enrike van der Linden,S. Hofmann,Rob Nelissen,Jaap M.J. den Toonder,Yolande Ramos
Capturing Essential Physiological Aspects of Interacting Cartilage and Bone Tissue with Osteoarthritis Pathophysiology: A Human Osteochondral Unit-on-a-Chip Model
Advanced Materials Technologies (2022) -
Stefan J.A. Remmers,Bregje W.M. de Wildt,Michelle A.M. Vis,Eva S.R. Spaander,Rob B.M. de Vries,Keita Ito,Sandra Hofmann
Osteoblast-osteoclast co-cultures
PLoS ONE (2021)
Ancillary Activities
No ancillary activities