Sylvia Roovers-Genet
Department / Institute
Group
RESEARCH PROFILE
Sylvia Genet is a PhD student working in the field of clinical chemistry with prof. dr. ir. Luc Brunsveld and prof. dr. Volkher Scharnhorst. Her project is based on a collaboration between the Laboratory of Chemical Biology at the TU/e and the clinical labs of the Catharina Hospital Eindhoven and Máxima Medical Center Eindhoven/Veldhoven. Her current research is focusing on the exploration of the clinical added value of protein biomarkers in diagnostics and monitoring of lung cancer and the development, validation and integration of a tandem mass spectrometry-based method for protein tumor marker analysis.
Keeping good diagnostics fast, minimally invasive and affordable is a main challenge in current health care; advanced diagnostic techniques in analytical chemistry pose a possible solution”
ACADEMIC BACKGROUND
Sylvia Genet studied Biomedical Engineering at the TU/e and obtained her Bachelor of Science degree in 2016. During her Bachelor she participated in the international student competition ‘SensUs’, where she worked in an interdisciplinary student team to develop a biosensor for monitoring creatinine levels for the detection of kidney failure. After that, she started her Master in the Chemical Biology group of prof. dr. ir. Luc Brunsveld at the TU/e, where she performed her graduation project under the supervision of dr. Christian Ottmann in collaboration with the industrial partner AstraZeneca. During this project she focused on the development of small‑molecule modulators for the 14-3-3-YAP/TAZ protein-protein interactions. Hereafter she went to the pharmaceutical company UCB in Slough (UK) to work on a fragment-based drug discovery project for the exploration of new techniques to target protein-protein interactions. Sylvia obtained her Master of Science degree in 2018 and to learn more about biomedical engineering in a clinical setting, she started her PhD at the TU/e in collaboration with the Catharina hospital Eindhoven and Máxima Medical Center Eindhoven/Veldhoven under supervision of prof. dr. ir. Luc Brunsveld and prof. dr. Volkher Scharnhorst.
Recent Publications
-
Esther Visser,Sylvia A.A.M. Genet,Remco P.P.A. de Kock,Ben E.E.M. van den Borne,Maggy Youssef-El Soud,Huub N.A. Belderbos,Gerben Stege,Marleen E.A. de Saegher,Susan C. van 't Westeinde,Luc Brunsveld
Liquid biopsy-based decision support algorithms for diagnosis and subtyping of lung cancer
Lung Cancer (2023) -
E. Visser,Remco P.P.A. de Kock,A.A.M. (Sylvia) Genet,Ben E.E.M. van den Borne,Maggy Youssef-El Soud,Huub N.A. Belderbos,Gerben Stege,Marleen E.A. de Saegher,Susan van 't Westeinde,Maarten A.C. Broeren
Up-front mutation detection in circulating tumor DNA by droplet digital PCR has added diagnostic value in lung cancer
Translational Oncology (2023) -
Remco de Kock,Ben van den Borne,Maggy Youssef-El Soud,Huub Belderbos,Gerben Stege,Marleen de Saegher,Claartje van Dongen-Schrover,Sylvia Genet,Luc Brunsveld,Volkher Scharnhorst
Circulating biomarkers for monitoring therapy response and detection of disease progression in lung cancer patients
Cancer Treatment and Research Communications (2021) -
Xavier Guillory,Madita Wolter,Seppe Leysen,Joao Filipe Neves,Ave Kuusk,Sylvia Genet,Bente Somsen,John Morrow,Emma Rivers,Lotte van Beek
Fragment-based Differential Targeting of PPI Stabilizer Interfaces
Journal of Medicinal Chemistry (2020) -
A.A.M. (Sylvia) Genet,E. Visser,Ben E.E.M. van den Borne,Maggy Youssef El Soud,Huub Belderbos,Gerben Stege,Marleen de Saegher,Federica Eduati,Maarten A.C. Broeren,Joost L.J. van Dongen
Correction of the NSE concentration in hemolyzed serum samples improves its diagnostic accuracy in small-cell lung cancer
Oncotarget (2020)
Ancillary Activities
No ancillary activities