Research in the Noël group encompasses the development of new catalytic strategies and technologies for chemical synthesis. The catalytic targets are chosen in such a way that continuous-flow microreactors and chemical engineering principles can make a substantial impact. By building bridges between chemical engineering and organic synthetic chemistry, long-standing problems in synthetic chemistry can be overcome. These includes scalability, gas-liquid reactions, photochemistry, electrochemistry and the generation and use of hazardous reagents. The unique approach at the interface of organic synthetic chemistry and chemical engineering enables the Noël group to rapidly recognize those synthetic problems that would benefit from microreactor technology. The group strives to develop new technological tools that are of interest to the pharmaceutical industry and can overcome challenges in a variety of specialty applications, e.g. organic synthesis, chemical biology, material science, etc. The ambition is to develop new catalytic strategies for chemical synthesis that engage novel reactivity concepts which facilitate the rapid generation of biologically active molecules. In the long run this would lead to an automated and chemo-catalytic equivalent to Nature’s biosynthetic machinery that is able to build essentially any molecule on demand.
Timothy Noël obtained his MSc in Industrial Chemical Engineering from KaHo Sint Lieven (Ghent, Belgium) in 2004. In 2009, he received his PhD at the Laboratory for Organic and Bioorganic Synthesis at Ghent University under supervision of Prof. Johan Van der Eycken with his thesis 'Synthesis and application of chiral dienes and chiral imidates for asymmetric transition metal catalysis'. He then moved to the Massachusetts Institute of Technology as a Fulbright Postdoctoral Fellow with Prof. Stephen L. Buchwald (MIT-Novartis Center for Continuous Manufacturing) where he worked on the development of new continuous-flow methods for cross-coupling chemistry. In 2012 he was appointed assistant professor at Eindhoven University of Technology (TU/e) and in 2017 associate professor with the research group Micro Flow Chemistry and Process Technology.
Biocatalytic synthesis of the Green Note trans-2-hexenal in a continuous-flow microreactorBeilstein Journal of Organic Chemistry (2018)
Accelerating visible-light photoredox catalysis in continuous-flow reactorsVisible light photocatalysis in organic chemistry (2018)
Selective C(sp3)−H aerobic oxidation enabled by decatungstate photocatalysis in flowAngewandte Chemie - International Edition (2018)
Microflow high-p,T intensification of vitamin D3 synthesis using an ultraviolet lampOrganic Process Research and Development (2018)
Continuous-Flow In-Line Solvent-Swap Crystallization of Vitamin D3Organic Process Research & Development (2018)
- Advanced organic chemistry
- Advanced organic chemistry
- Introduction chemistry and chemical technology
- Graduation Project MSMC
- Inorganic chemistry and materials
- Practical introduction course to chemistry and chemical technology
- Associate editor, Journal of Flow Chemistry