Tommaso Ristori

Tommaso Ristori is Assistant Professor at the TU/e, in the Biomedical Engineering Department. His research mainly focuses on investigating blood vessel formation and designing regenerative medicine approaches to induce physiological vascularization of diseased and engineered tissues. Particular attention is devoted to the mechanobiology and cell signaling underlying sprouting angiogenesis, the process leading to the formation of new blood vessels from pre-existing ones. Controlling this process is not only the target of several medical therapies, but also key to enable the development of relatively large tissue-engineered constructs ,such as tissue-engineered bones.

To unravel the mechanisms of angiogenesis, Tommaso Ristori develops multiscale computational models synergistically integrated with targeted experiments, essential to inform and validate the simulations. Moreover, strategies to better leverage on this integration between simulations and experiments are also developed.

Current projects focus on developing computational models of the (mechanosensitive) cell signaling pathways regulating angiogenesis, and on the validation of the resulting simulations via 2D and 3D cell culture experiments.