STW grant for new molecular technology for biosensing applications

Menno Prins and Arthur de Jong received an STW grant to develop a new modular technology to molecularly coat surfaces for biosensing applications. The TU/e researchers collaborate with Wageningen University & Research (WUR) and several companies to investigate the new molecular concept. Ultimately, they will demonstrate the technology in a point-of-care test for the molecule troponin, a key biomarker for diagnosing heart attacks.

The research group Molecular Biosensing for Medical Diagnostics (MBx) of Prof. Menno Prins and Arthur de Jong investigates technologies to detect and monitor molecules and molecular processes with single-molecule resolution. Such technologies reveal novel characteristics of the molecules, e.g. distributions of molecular properties such as affinity or kinetic parameters. With this STW grant, they want to develop a new concept in which antibodies will be linked by a polypeptide to polymer brushes that are coated onto a sensor surface, in order to create biosensing surfaces with high antibody activity and good antifouling properties. WUR will develop the polypeptide linkers and antibody conjugations and MBx will characterize the surface functionality with single molecule techniques.

Dr.ir. Arthur de Jong

Arthur de Jong studied Chemical Technology at Eindhoven University of Technology. He received a PhD in the field of surface science and catalysis in 1994. Thereafter he worked on catalytic reaction engineering as a postdoc. In 2000 he was employed as assistant professor in the department of Applied Physics of TU/e and worked in the group of accelerator applications. Since 2005 he works in the group MBx. He is a core member of the Institute for Complex Molecular Systems (ICMS).

Prof. Menno Prins

Prof. Prins studied Applied Physics at Delft University of Technology (cum laude). He received a PhD from Radboud University Nijmegen in 1995. Thereafter he moved to Philips Research where he worked on microfluidics and point-of-care biosensing. Since 2005 he also worked as parttime professor at TU/e. Since 2014 prof. Prins is fulltime professor in the departments of BioMedical Engineering and Applied Physics, in the field of Molecular Biosensing for Medical Diagnostics (MBx). The research focuses on novel detection principles and novel molecular systems for particle-based in-vitro and in-vivo biosensing, aiming at biomolecular detection in complex environments with high sensitivity, specificity and biocompatibility. The activities are part of the Institute for Complex Molecular Systems (ICMS) and the Strategic Area Health (SA Health).