Master Student Project – Molecular dynamics (MD) simulation on polymeric vesicle architecture
Polymersomes are an interesting group of polymeric (micro/nano) vesicles. These vesicles are formed due to the self-assembly of amphiphilic block copolymers into a well-defined nano/micro structure (100- 500 nm). For biological systems (uptake, cell response, etc.) the morphology (size, shape, membrane thickness) of these polymersomes is highly important and, consequently, we are interested in controlling and understanding these parameters.
The goal of this master project is to use computer simulations to calculate the folding of the used block copolymers and its interactions, to correlate its composition to the morphology of the polymeric vesicles.
Master Student Project - Microfluidic production of giant liposomes
There are several established methods to make giant (> 1 um) liposomes, each with their own advantages and drawbacks. In recent years, the fabrication of these giant liposomes using microfluidics has proven to be very interesting due to its high reproducibility and high loading efficiency. For instance, it is possible to load giant liposomes with cell extract and a synthetic plasmid, permitting the production of your protein of interest in a cell-like vesicle. In our group, we want to load liposomes with enzymatic cascades, to create communicating colonies of artificial cells, or to use them to deliver nanoparticles to cells. Microfluidic fabrication of liposomes would greatly help us, since it is reliable, with high efficiency and throughput.
Bachelor End Projects 2016/17 – Laboratory of Chemical Biology
Stimulus-responsive particles for nanomedicine
Nanomedicine is regarded as one of the most promising developments to improve the efficacy of a wide range of biomedical activities, such as drug delivery and vaccination. For this purpose, nanoparticles need to be constructed with tailor-made size, shape and surface functionality. In this BEP students will construct the polymer building blocks, either via protein engineering or polymer chemistry, and investigate the assembly process. They will study how the particle properties depend on environmental changes such as pH and temperature.