Dr. David Williams
After graduating from Durham University in 2008, with a masters degree in chemistry, Dr. Williams joined the Centre for Organized Matter Chemistry (COMC) at the University of Bristol where he completed his PhD under the supervision of Prof. Stephen Mann FRS in 2012 (doctoral thesis was awarded a faculty of science commendation). In 2014, Dr. Williams continued his postdoctoral research by joining the Bio-Organic chemistry group of Prof. Jan van Hest (Nijmegen) in order to pursue research at the interface between materials chemistry and biomedical technology. With the recent move of the Bio-Organic chemistry group to TU/e, Dr. Williams has been appointed as a research fellow in order to develop research themes into the design and implementation of biodegradable polymeric nanostructures as drug delivery vectors, artificial organelles and cell-mimetic systems; working with an enthusiastic and talented team of PhD and postdoctoral researchers.
(1) Artificial Organelles
Delivering multi-functional polymersomes into cells is a complex objective that requires careful tuning of surface properties, size and shape. Moreover, different cell types have distinct surface characteristics than can be exploited for cell-specific uptake in the engineering ‘smart’ nanoreactors that, upon cellular inclusion, take their role in determining intracellular chemistry.
(2) Drug Delivery
Developing polymeric nanoparticles for use in cancer therapeutics is an exciting prospect with direct applications in the ‘real-world’. By controlling the morphology and size of various biodegradable polymer-based nanoparticles we create a library of delivery vehicles that, after drug-incorporation, can be investigated for in vitro and in vivo efficacy in addressing certain types of cancer.
(3) Artificial cell-like systems
By constructing an assortment of microscopic polymeric architectures we can create artificial scenarios that mimic aspects of cellular function such as communication, replication and metabolism.
“Formation of Well-Defined, Functional Nanotubes via Osmotically Induced Shape Transformation of Biodegradable Polymersomes” - D.S. Williams, L.K.E.A. Abdelmohsen, J. Pille, S.G. Ozel, R.S.M. Rikken, D.A. Wilson and J.C.M. van Hest, J. Am Chem Soc., 2016, 138, 9353-9356.
“Spontaneous Structuration in Coacervate‐Based Protocells by Polyoxometalate‐Mediated Membrane Assembly” - D.S. Williams, A.J. Patil and S. Mann, Small, 2014, 10, 1830-1840.
“Fatty acid membrane assembly on coacervate microdroplets as a step towards a hybrid protocell model” - T.Y.D. Tang, C.R.C. Hak, A.J. Thompson, M.K. Kuimova, D.S. Williams, A.W. Perriman, S. Mann, Nature Chemistry, 2014, 6, 527-533.
X. Huang, M. Li, D.G. Green, D.S. Williams, A.J. Patil and S. Mann, Nature Communications, 2013, 4, 2239.
Y.-Y. Kim, D.S. Williams, F.C. Meldrum, D. Walsh, Small, 2013, 9, 61-66.
J. Crosby, T. Treadwell, M. Hammerton, K. Vasilakis, M.P. Crump, D.S. Williams and S. Mann, Chem. Commun., 2012, 48, 11832-11834.
D.S. Williams, S. Koga, C.R.C. Hak, A. Majrekar, A.J. Patil, A.W. Perriman and S. Mann, Soft Matter, 2012, 8, 6004-6016.
S. Koga, D.S. Williams, A.W. Perriman and S. Mann, Nature Chemistry, 2011, 3, 720-724.
A.W. Perriman, D.S. Williams, A.J. Jackson, I. Grillo, J.M. Koomullil, A. Ghasparian, J.A. Robinson and S. Mann, Small, 2009, 6, 1191-1196.