Born and raised in France, Roxane has developed a passion for nanomedicine. Before graduating in 2016 with a MSc in Chemistry and Physics with a speciality in polymers and formulation from Ecole Nationale Supérieure de Chimie, Biologie et Physique de Bordeaux (Pessac, France), Roxane did two internships working on drug delivery systems. First, she worked in the Pr. Vincent Rotello’s group at UMASS (Amherst, Massachusetts, USA), where she developed polymer-based nanospheres for delivery applications (cancer therapy and biofilm treatment). Then, she joined the Pr. Jan van Hest’s group at the Radboud University (Nijmegen, The Netherlands), where she worked on biodegradable polymer-based micelles formulation and characterization for drug delivery to treat leukemia.
Nowadays, Roxane is a PhD student at TU/e (Eindhoven, The Netherlands), linked to Pr. Jan van Hest’s group. Her project is called Particle Shape Effect and takes part of the European framework NANOMED.
The objective of this project is to establish the effect micelle and polymersome shape has on drug release and cell uptake. Different shapes lead to different interaction surfaces between cells and particles. This will affect cell uptake and particle biodistribution.
A focus will be made on retinal drug delivery. All particles are composed of biodegradable block copolymers and the degradation behavior will be investigated.