Blood in Motion
Cardiovascular diseases, disorders, and events, such as coronary artery disease, aneurysms, stroke, and thrombosis occur at specific regions in the circulation and may lead to significant local blood flow alterations. Moreover, hemodynamic factors are believed to play an important role in the development of these diseases.
Aim in the track ‘Blood in Motion’ is to develop mathematical models that simulate blood flow in specific arteries in order to obtain insight into the occurrence of vascular diseases and to assist in patient specific intervention planning (e.g. angioplasty, valve replacement and vascular access surgery). As every artery is part of the complete circulation, it can not be modelled as a simple bounded entity. That is why special attention is paid to applying proper boundary conditions depending on pulse wave propagation and reflection in the arterial tree.
The mathematical models are verified using in vitro set-ups and are validated in clinical trials in collaboration with our clinical partners. To make the models patient specific and implement them in current clinical workflows, advanced global sensitivity and uncertainty analysis methods are developed and applied.
Vascular access for dialysis patients
More than 500.000 patients with end stage renal disease (ESRD) rely on hemodialysis therapy. The successful creation of vascular...Read more
Diagnosis and intervention in coronary artery disease
Coronary artery disease, in which the coronary arteries are partly or totally obstructed by atherosclerotic plaques (stenosis), is...Read more
Diagnosis and intervention in peripheral circulation disease and disorders
The study of flow in the peripheral circulation is important for the diagnosis and intervention in peripheral artery disease such...Read more
Flow and autoregulation in cerebral arteries
Ischemic and hemorrhagic stroke occur 15-20 million times a year and form a major cause of maternal mortality and morbidity.Read more
Measuring tissue perfusion is valuable for diagnosis and treatment monitoring in numerous diseases. Photo-acoustic (PA) imaging,...Read more