Metal nanoparticles provide the possibility to detect single molecules without the need for labeling, enabling the direct detection of non-absorbing species . A molecule that binds to receptors on the surface of a particle induces a change in the local refractive index that in turn results in a change of color due to a shift of the plasmon resonance [2,3]. This animation illustrates the real-time detection of plasmon shifts induced by molecules binding to functionalized single gold nanorods. The plasmon shifts are measured by monitoring scattering intensities of many particles simultaneously and in real-time .
The motion of four particles is tracked over time in order to reveal different binding types. See E.W.A. Visser, L.J. van IJzendoorn, M.W.J. Prins, Proc. MicroTAS (2014).
The process of technological innovation is an interplay between people of different backgrounds and perspectives: scientists, technologists, application experts, and business people. In this video Menno Prins describes how these people interact, how activities translate between the people, and how the translation feeds the innovation process. Menno Prins is a professor at Eindhoven University of Technology.