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Musculoskeletal tissues are produced, maintained and adapted by cells as a response to their biophysical environment in health and disease. Of the latter, degenerative diseases have become more prevalent with an increasing socioeconomic impact in our ever aging population. With increased longevity and a higher level of activity, current treatment methods with purely synthetic devices may be limited.

In the Orthopaedic Biomechanics research group, the disciplines of engineering and biology are combined to expand our understanding of the biomechanical function of musculoskeletal tissues as well as their adaptive developmental and physiological nature. This knowledge is then applied to explore and develop regenerative treatment strategies, currently applied to three musculoskeletal tissues, i.e. bone, articular cartilage, intervertebral disc and tendons/ligaments.