Osteoarthritis and cartilage tissue engineering

Dr. René van Donkelaar

Degenerative joint disease, another common musculoskeletal disease, is believed to be a result of disturbed balance between strength of articular cartilage, joint loading, and lack of biological repair. Computational and in vitro models are used to delineate its cause and pathogenesis. Once damaged or degraded, surgical intervention is often necessary. Cartilage regeneration is an attractive treatment method in such interventions. Unfortunately current methods could be much improved. We believe that proper tissue conditioning can result in better tissue ultrastructure and function. Using a multidisciplinary approach, computational models are used to optimize tissue conditions and combined with in vitro experiments for model development, validation and final proof of concepts studies.

Current projects

Recent projects

Past projects

Mechanoregulation of bone adaptation in osteoarthritits

Cox, L.G.E. (2011). Mechanoregulated bone adaptation in osteoarthritis. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr. K. Ito, dr. C.C. van Donkelaar & dr.ir. B. van Rietbergen).

Control of long bone growth

Foolen, J. (2009). How periosteum is involved in long bone growth. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr. K. Ito, prof.dr.ir. R. Huiskes & dr. C.C. van Donkelaar).

Mechanics of cartilage and cartilage damage

Wilson, W. (2005). An explanation for the onset of mechanically induced cartilage damage. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr.ir. R. Huiskes, dr. C.C. van Donkelaar & dr.ir. B. van Rietbergen).

Mechanobiology of bone fracture repair

Isaksson, H.E. (2007). Mechanical and mechanobiological influences on bone fracture repair : identifying important cellular characteristics. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr.ir. R. Huiskes, prof.dr. K. Ito & dr. C.C. van Donkelaar).