Osteoarthritis and cartilage tissue engineering
Degenerative joint disease, another common musculoskeletal disease, is believed to be a result of disturbed balance between strength of articular cartilage, joint loading, and lack of biological repair. Computational and in vitro models are used to delineate its cause and pathogenesis. Once damaged or degraded, surgical intervention is often necessary. Cartilage regeneration is an attractive treatment method in such interventions. Unfortunately current methods could be much improved. We believe that proper tissue conditioning can result in better tissue ultrastructure and function. Using a multidisciplinary approach, computational models are used to optimize tissue conditions and combined with in vitro experiments for model development, validation and final proof of concepts studies.
Numerical design and development of a meniscus implant based on functionality and tissue damage
The knee meniscus is a wedge shaped cartilaginous tissue located in the knee joints between the femoral condyles and the tibia...Read more
Strain-induced initiation and progression of articular cartilage damage
Cartilage is a thin, white, smooth and glistening layer that covers diarthrodial joints. It’s aneural and without blood supply. ...Read more
A synthetic non-degrading, non-drug releasing cartilage implant
Cartilage defects are found in 63% of arthroscopic procedures, often in middle-aged patients. Operations to restore the cartilage...Read more
Patient specific prognosis of disease progression in osteoarthritis
Osteoarthritis (OA) involves degeneration of articular cartilage and changes to underlying bone. Because cartilage has limited...Read more
Computer-aided tissue engineering of articular cartilage with physiological collagen architecture
The objective of this project is to engineer articular cartilage with improved biomechanical properties and a physiological...Read more
Mechanoregulation of bone adaptation in osteoarthritits
Cox, L.G.E. (2011). Mechanoregulated bone adaptation in osteoarthritis. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr. K. Ito, dr. C.C. van Donkelaar & dr.ir. B. van Rietbergen).
Control of long bone growth
Foolen, J. (2009). How periosteum is involved in long bone growth. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr. K. Ito, prof.dr.ir. R. Huiskes & dr. C.C. van Donkelaar).
Mechanics of cartilage and cartilage damage
Wilson, W. (2005). An explanation for the onset of mechanically induced cartilage damage. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr.ir. R. Huiskes, dr. C.C. van Donkelaar & dr.ir. B. van Rietbergen).
Mechanobiology of bone fracture repair
Isaksson, H.E. (2007). Mechanical and mechanobiological influences on bone fracture repair : identifying important cellular characteristics. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr.ir. R. Huiskes, prof.dr. K. Ito & dr. C.C. van Donkelaar).