Intervertebral disc

Prof.dr. Keita Ito

Low back pain is one of the most common causes of disability for individuals of working age in developed countries. There are many causes of low back pain, and it is generally believed that degenerative disc disease is one of the most prevalent. The goal is to understand the basic mechanisms of disc degeneration and to develop long-term functional treatments for this condition.

The strategy focuses on: exploring deficient nutrition and mechanical loading as mechanotransduction mechanisms of cellular stimulated degeneration; how these degenerative changes may cause failure of disc function; and then using this understanding to explore tissue engineering approaches towards disc regeneration. The approach is to combine numerical simulations of continuum mechanics, mass transport, and biological process to that of in vitro experiments.

Current projects

Recent projects

Past projects

Can notochordal cells promote disc matrix formation by mesenchymal stem cells and nucleus pulposus cells?

Potier, E. (2012). Can notochordal cells promote disc matrix formation by mesenchymal stem cells and nucleus pulposus cells? Eindhoven: Technische Universiteit Eindhoven. (Promot: prof.dr. K. Ito).

A loaded intervertebral disc tissue culture system

Dijk, B.G.M. van (2013). A physiological in vitro model of intervertebral disc tissue. Eindhoven: Technische Universiteit Eindhoven. (Promot.: prof.dr. K. Ito).

Development of a biomimetic artificial intervertebral disc

Broek, P.R. van den (2012). Development of a biomimetic artificial intervertebral disc. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr. K. Ito & dr.ir. J.M.R.J. Huyghe)

How periosteum is involved in long bone growth

Foolen, J. (2009). How periosteum is involved in long bone growth. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr. K. Ito, prof.dr.ir. R. Huiskes & dr. C.C. van Donkelaar).

The influence of nutrient deprivation on nucleus pulposus cells in vivo and in vitro

Werf, M.J. van der (2009). The influence of nutrient deprivation on nucleus pulposus cells in vivo and in vitro. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr. K. Ito & dr. C.C. van Donkelaar).

Putting pressure on the spine : an osmoviscoelastic FE model of the intervertebral disc

Schröder, Y. (2008). Putting pressure on the spine : an osmoviscoelastic FE model of the intervertebral disc. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr.ir. F.P.T. Baaijens, prof.dr. K. Ito & dr.ir. J.M.R.J. Huyghe).