Tendon and Ligament Mechanobiology
Tendon and ligament injuries are involved in over 30% of all musculoskeletal consultations. The poor innate regenerative capacity, controversy concerning adequate treatment and poor clinical outcome of surgical interventions, results in limited progress in the treatment of tendinopathy and connective tissue fibrosis/scarring over the past decades. Our goal is to explore mechanobiological processes that initiate degeneration and promote healing of tendon/ligament. Experimental platforms, e.g. biomimetic tendons/ligaments, are exploited in combination with numerical models to develop strategies to improve the structure and functionality of affected tendon/ligament.
The role of cellular junctions in tendon tissue organization
Determine the presence, localization and function of cellular junctions in primary tendon cells, and investigate whether restoring...Read more
The impact of cellular organization in 3D tissue on the healing capacity of tendon-derived cells
Tendinopathy associates with a change from a healthy tissue with aligned ECM and highly polarized cells that are connected...Read more