This initiative is being carried out by biomedical engineers and clinicians from the Eindhoven University of Technology (TU/e), the Erasmus Medical Center (EMC) and the University Medical Center Utrecht (UMCU).

Research Leaders of 1VALVE

Carlijn VC Bouten, PhD, Professor of Cell-Matrix interactions in Cardiovascular Regeneration, Department of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, Netherlands

Carlijn Bouten studies the interplay between cells, extracellular matrix, and synthetic materials using ‘living’ engineered models systems of healthy and diseased cardiovascular tissues to develop in-situ tissue regeneration approaches. She is founding fellow of the European Alliance for Medical and Biological Engineering and Science (EAMBES) and member of the ESC working group on Myocardial Function. Her research in the 1Valve project concentrates on the effect of scaffold architecture on cell and tissue homeostasis.

A Pieter Kappetein, MD, PhD, Professor of Cardio-thoracic Surgery, Erasmus MC, Rotterdam, Netherlands.

Pieter Kappetein is surgeon with specific interest in the introduction and evaluation of new techniques for treatment of cardiovascular diseases. He is Secretary General of the European Association for Cardio-thoracic surgery and is steering committee member of various clinical trials.

Together with professor Frank Baaijens he is research leader of 1Valve. He will focus on the implantation of tissue engineered heart valves using minimally invasive techniques. In addition, he will be responsible for developing protocols for the first in man application and apply for approval for the implantation of the first tissue engineered heart valve.

Principal Investigators of 1VALVE

Patricia YW Dankers, PhD, Assistant professor, Eindhoven University of Technology, Department of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, Netherlands
Patricia Dankers studied chemistry at the Radboud University of Nijmegen and obtained her PhD from the Eindhoven University of Technology.  She worked for the company SupraPolix, in the laboratory of Pathology and Medical Biology at the University Medical Center Groningen, and in the Institute for BioNanotechnology in Medicine at Northwestern University, Chicago. Her research interest lies in the synthesis and biomedical application of functional supramolecular biomaterials for regenerative medicine. In the 1Valve project she will develop new bioactive scaffolds for in-situ heart valve regeneration.

Jolanda Kluin, MD, PhD, Cardiothoracic surgeon, University Medical Center Utrecht, Netherlands

Jolanda Kluin studied medicine at the Erasmus University Rotterdam, the Netherlands. In 2006 she finished her residency and became a staff member at the Department of Cardiothoracic Surgery of the UMC Utrecht. Reconstructive cardiac surgery (valvular, aortic and GUCH) and heart and lung transplantations have her special interest. Next to her clinical tasks and clinical research she leads the preclinical research line at the department. Within the 1Valve project she addresses the in-vivo experiments in large and small animals.

Johanna JM Takkenberg, MD, PhD, Professor of Clinical Decision making in Cardio-Thoracic Interventions, Department of Cardio-Thoracic Surgery, Erasmus MC, Rotterdam, Netherlands.

Hanneke Takkenberg is a clinical epidemiologist with a specific expertise in prognostic modeling and clinical decision making in valvular heart disease. She is Council member of the Society for Heart Valve Disease and member of the 2012 EACTS/ESC Valvular Heart Disease Taskforce. Within 1Vlave she will address early health technology assessment of gold standard heart valve substitutes and in-situ tissue-engineered valves, and define optimal strategies for the introduction of tissue-engineered valves.

Sandra Loerakker, PhD, Assistant professor of Modeling in Mechanobiology, Department of Biomedical Engineering, and Institute for Complex Molecular Systems, Eindhoven University of Technology, The Netherlands.

Sandra Loerakker studied Biomedical Engineering at the Eindhoven University of Technology, and obtained her PhD in 2011. Her main research interests are the mechanical factors involved in growth and remodeling of native and engineered tissues, with a particular focus on the integration of continuum mechanics and (cell) biology. Her research in the 1Valve project concentrates on determining the effects of scaffold design on cell traction and tissue formation.