Key ImaValve scientists at TU/e

Carlijn V.C. Bouten is full professor in the department of Biomedical Engineering of the Eindhoven University of Technology (TU/e, research group for Soft Tissue Engineering & Mechanobiology). She was trained in functional anatomy and biomechanics, as well as exercise physiology, at the department of Human Movement Sciences, VU Amsterdam (MSc 1991), and obtained her PhD degree in 1995 from the TU/e. She performed postdoctoral research at the Université Laval (Quebec), University of London, and Eindhoven University of Technology. In 1998 she became assistant professor in Cellular Biomechanics in the department of Mechanical Engineering, TU/e, and in 2002 she became associate professor of Tissue Engineering in the department of Biomedical Engineering, TU/e.  Her current research focuses on cell-matrix interactions in cardiovascular tissues, with special emphasis on regulating growth, differentiation, adaptation and remodeling. She uses ‘living’ model systems at different length scales (cell, cell-matrix, engineered tissue, native tissue) to quantify these aspects, preferably in real-time.

Prof. Bouten will coordinate the ImaValve consortium and lead the research of the PhD students enrolled from TU/e, in close collaboration with prof. Dankers and prof. Salhgren.

Patricia Y.W. Dankers is associate professor of Supramolecular Biomaterials for Translational Biomedical Science, in the Laboratory of Chemical Biology in the Biomedical Engineering (BME) department, and in the Institute for Complex Molecular Systems, at TU/e. Prof. Dankers studied Chemistry at the Radboud University in Nijmegen. In 2002 she started her first PhD at the Eindhoven University of Technology (TU/e). Under supervision of prof. dr. E.W. (Bert) Meijer she investigated supramolecular biomaterials by introducing a modular approach. In a second PhD in Medical Sciences at the University of Groningen she worked on renal regenerative medicine (2013). Additionally, she worked for the company SupraPolix, in the laboratory of Pathology and Medical Biology at the University Medical Center Groningen, and in the Institute for BioNanotechnology in Medicine at Northwestern University, Chicago. Her current particular research interests are on the design and synthesis of bioinspired functional biomaterials in the field of regenerative medicine.

Prof. Dankers will be one of the principal investigators for ImaValve, developing new bioactive scaffolds for in-situ heart valve regeneration.

Cecilia Sahlgren is assistant professor in the group of Soft Tissue Engineering & Mechanobiology at the Department of Biomedical Engineering in Eindhoven. Moreover, prof. Sahlgren has an affiliation as a principle Investigator at the Abo Akademi University, Finland. She has a background in cell and molecular biology. Her main research focus involves the understanding the basic molecular principles of signaling mechanisms regulating cell fate choices during stem cell differentiation, and how disturbances in these mechanisms link to diseaser. Prof. Sahlgren is particularly interested in the role and regulation of the evolutionary conserved Notch signaling
pathway, a key regulator of stem cell function, cardiovascular development and tumorigenesis.

Prof. Sahlgren is one of the principal investigators for ImaValve, focusing on Notch signalling pathways related to de novo tissue formation in cardiovascular tissue engineering.