Dr. Amy Yewdall
After completing her B.A. and M.Sci. in Biochemistry from the University of Cambridge, Amy pursued a PhD at the University of Canterbury in New Zealand under the supervision of Professor Juliet Gerrard. There she cultivated a passion for repurposing biological materials for use in new contexts. Her expertise in protein engineering, assays, structural biology and bionanotechnology, equips her with a fresh biological perspective towards projects within the van Hest group as a postdoctoral researcher.
Integrating biological systems into synthetic compartments
It is fascinating how seemingly lifeless chemical and molecular exchanges can organise into complex living organisms. To explore this complexity, certain aspects of life – such as compartmentalisation of macromolecular crowding – can be mimicked using synthetic systems, such as polymersomes or coacervates. These micro-to-nanoscale compartments can segregate and concentrate biological components, such as enzyme networks or organelles, thereby imitating the crowded intracellular environment. Mimicking living cells by recreating aspects of their complexity can not only enhance our understanding of the processes involved in supporting life, but also innovate new technologies.
Yewdall NA, Venugopal H, Desfosses A, Abrishami V, Yosaatmadja Y, Hampton MB, Gerrard JA, Goldstone DC, Mitra AK, Radjainia M (2016) Structures of Human Peroxiredoxin 3 Suggest Self-Chaperoning Assembly that Maintains Catalytic State. Structure 24: 1120-9
Malmstrom J, Wason A, Roache F, Yewdall NA, Radjainia M, Wei S, Higgins MJ, Williams DE, Gerrard JA, Travas-Sejdic J (2015) Protein nanorings organized by poly(styrene-block-ethylene oxide) self-assembled thin films. Nanoscale 7: 19940-19948
Radjainia M, Venugopal H, Desfosses A, Phillips Amy J, Yewdall NA, Hampton Mark B, Gerrard Juliet A, Mitra Alok K (2015) Cryo-Electron Microscopy Structure of Human Peroxiredoxin-3 Filament Reveals the Assembly of a Putative Chaperone. Structure 23: 912-920
Phillips AJ, Littlejohn J, Yewdall NA, Zhu T, Valéry C, Pearce FG, Mitra AK, Radjainia M, Gerrard JA (2014) Peroxiredoxin is a versatile self-assembling tecton for protein nanotechnology. Biomacromolecules 15: 1871-1881