Jan Pille (1988, Mettingen) received his M.Sc. in molecular biotechnology from the Uppsala University in 2014. During his master, founded by the German Academic Exchange Service (DAAD) and the German Academic Scholarship Foundation, he worked in the lab of Prof. S. Sanyal (Uppsala University) and Prof. W. Huck (Radboud University, the Netherlands) on protein translation and noise in cell-free gene expression systems. As of September 2014, he works in the group of Prof. J.C.M. van Hest, where he worked before on creating virus-based supramolecular scaffold in collaboration with T. Michon (INRA, Bordeaux, France) during his bachelor. His work focuses on using elastin-like peptides as carrier nanoparticles to cross the blood-brain barrier.
Elastin-like peptide nanoparticles for nanomedicine
Elastin-like peptides are thermoresponsive proteins that can be designed to form nanoparticles at physiological conditions. They are stable and biocompatible and therefore suitable to be used in nanomedicine. We are developing them as a carrier platform to deliver protein, peptides and therapeutic molecules into the brain. We have e.g. successfully developed particles that display llama heavy-chain antibody fragments (VHHs or nanobodies) and have shown that they can identify and kill cancer cells expressing the epidermal growth factor receptor (EGFR) efficiently by photodynamic therapy.
J. Pille; D. Cardinale; N. Carette; C. Di Primo; J. Besong-Ndika; J. Walter; H. Lecoq; M. B. van Eldijk; F. C. Smits; S. Schoffelen; J. C. van Hest; K. Makinen; T. Michon, Biomacromolecules 2013, 14, 4351.
L. Schoonen; J. Pille; A. Borrmann; R. J. Nolte; J. C. van Hest, Bioconjug Chem 2015, 26, 2429.
J. Besong-Ndika; M. Wahlsten; D. Cardinale; J. Pille; J. Walter; T. Michon; K. Makinen, Front Plant Sci 2016, 7, 89.
L. K. Abdelmohsen; D. S. Williams; J. Pille; S. G. Ozel; R. S. Rikken; D. A. Wilson; J. C. van Hest, J Am Chem Soc 2016, 138, 9353.