Research topics

The research and teaching program of the BioMedical NMR group is aimed at the development and use of in vivo magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques. MRI and MRS offer exciting possibilities for the investigation of a range of structural, functional and metabolic parameters in living systems.

MRI and MRS are non-invasive and therefore ideally suited for repeated studies, in which changes in tissues are followed over time. This non-invasiveness and the richness of the information that is obtained explain the important role of MR in biological and biomedical research. Not surprisingly, MR has also rapidly gained an important position in human healthcare since its first arrival in medical centers in the late 1980’s.

The central aim of our research program is to push the limits of biomedical MR. New techniques are developed and validated by studies on biological preparations in vitro and animal models in vivo, and where possible applied in clinical human research. The technology developments in our group are inspired by important biomedical and healthcare problems:

  1. skeletal muscle disorders, especially type 2 diabetes and decubitus;
  2. cardiovascular disorders, including atherosclerosis and cardiac infarction;
  3. molecular imaging of disease biomarkers and the development of target-specific contrast agents.

These themes were chosen because:

  1. diseases of skeletal muscle and the cardiovascular system have a major socio-economic impact;
  2. MR has the potential to greatly improve the diagnosis and management of these disorders;
  3. novel MRI protocols combined with targeted contrast agents can strongly enhance the specificity and sensitivity of diagnostic MRI.

Find more information on the research topics below;