Ir. Anniek den Hamer

Biography

Anniek den Hamer (1989) studied Biomedical Engineering at Eindhoven University of Technology (TU/e), receiving her Bachelor degree in 2011. During her master she performed an internship in the Protein Engineering group of Dr. Maarten Merkx, developing a homogenous assay using split-beta-lactamases for the detection of antibodies. For her next internship she joined the group of Professor Matt Cooper, at the Institute of Molecular Bioscience of the University of Queensland in Brisbane (Australia), where she developed hybrid fluoro- magnetic nanoparticles for serotyping of Dengue fever. Anniek performed her graduation project in the Chemical Biology group of Professor Luc Brunsveld, where she characterized the interaction of 14-3-3 proteins with nuclear estrogen receptor alpha as a potential drug target for breast cancer. This project was in close collaboration with the Chemical Genomics Centre of the Max Planck Institute in Dortmund. Anniek received her master degree at the TU/e in 2013. She continued as a PhD candidate in the group of Professor Luc Brunsveld. Her project aims to engineer small synthetic signaling networks with a central role for the scaffold protein 14-3-3 functioning as small molecule controlled dimerization platform. As a proof of principle, caspases are used to show proximity induced dimerization and therefore activation upon addition of the small molecule stabilizer fusicoccin to the 14-3-3 scaffold. Her research involves techniques such as mutagenesis, protein expression and purification, cell culturing and fluorescence microscopy. In her project Anniek uses a combination of protein engineering, chemical biology and synthetic biology approaches to gain fundamental insights into scaffold protein mediated signal transduction.

Contact

Office: ST 3.28
Phone: 040-247 8756
E-mail: a.d.hamer@tue.nl