Ir. Chan Vinh Lam
Research has shown that our environment can influence how our body functions by introducing small reversible modifications on proteins. In particular, these so-called post translational modifications (PTMs) of large hormone-controlled nuclear receptor proteins are interesting. These proteins control thousands of processes and their altered functioning due to PTMs lead to many diseases like cancer and diabetes. Unfortunately, our understanding of how PTMs function on the molecular level is minimal yet crucial in finding a cure for these diseases. My research therefore focuses on trying to understand these PTMs for the PPARγ nuclear receptor by recreating them in vitro using protein semi-synthesis , peptide synthesis and in cell mutational studies.