Ir. Sebastian Andrei
Sebastian Andrei (1990) obtained his bachelor’s degree in chemical engineering in 2013 at the Eindhoven University of Technology. His bachelor’s thesis focused on synthesizing tags for the supramolecular immobilization of proteins. He used the ferrocene - cucurbituril host – guest interaction to immobilize proteins on gold surfaces, intended for SR measurements. He then continued to obtain is his master’s degree in biomedical engineering in 2015. He graduated on the synthesis of bisbenzannulated-6,6-spiroketals as agonists for the Retinoid X Receptor, under the guidance of prof. dr. ir. Luc Brunsveld. He attempted to develop novel synthetic methods towards these molecules and performed crystallographic studies on their binding. After his master’s thesis, he went on an industrial placement with AstraZeneca in Mölndal, Sweden. In a cooperation with dr. Gavin O’Mahony (AstraZeneca) and dr. Christian Ottmann (Eindhoven University of Technology), he developed a method for the parallel synthesis of a library of Epibestatin analogues, designed for the stabilization of 14-3-3 protein-protein interactions. After synthesizing this library, he started his PhD. in the lab of dr. Christian Ottmann and prof. dr. ir. Luc Brunsveld, where he continued his research on stabilizers of 14-3-3 protein-protein interactions using these molecules as tool compounds. He uses small molecules, natural product semi-synthesis and peptide synthesis, driven by X-ray crystallography and biochemical characterization, to identify and develop stabilizers of 14-3-3 protein-protein interactions.