Strong reduction of spectral heterogeneity for single-molecule plasmon sensing

In a typical plasmonic biosensor the binding of analyte to a functional particle results in a plasmon shift that can be conveniently monitored in a far-field optical microscope. Heterogeneities in spectral properties of individual particles in an ensemble affect the reliability of a single-particle plasmon sensor. This is especially the case when plasmon shifts are monitored in real-time using a fixed irradiation wavelength. Researchers at MBx now show that gold bipyramids exhibit a strongly reduced spectral heterogeneity, which translates into a significantly improved homogeneity of the response to molecular binding. This finding will lead to faster and more reliable single-particle and single-molecule plasmon sensors. Read more here: