Bachelor end projects

Course Description
The Bachelor End Project (BEP) is an introduction into performing an individual research project. You will learn how to formulate a research question with the corresponding hypothesis and to design the right experiments or simulations to answer your research question. Different practical and analytical skills will be developed and improved, depending on the topic of the project. Finally, you will learn how to summarize the obtained insights in a scientific report and presentation.

Applying and Selection

  • To apply for a BEP, subscribe to 8Z4000 on Osiris.
  • The ‘onderwijsbureau’ will then check eligibility and send you an application form.
  • Depending on availability, you will be assigned to our group.
  • We will then ask you to choose 3 subgroups and try to assign everyone to their first pick:
    • Bone biomechanics (biomechanics, numerical and/or experimental), Bert van Rietbergen
    • Bone tissue engineering (experimental), Sandra Hofmann
    • Articular Cartilage (numerical and/or experimental, Rene van Donkelaar
    • Intervertebral Disc (experimental), Keita Ito
    • Tendon & Ligaments (experimental), Jasper Foolen
  • You then sign the form and bring it to the coordinator (Jasper Foolen, GemZ 4.102)
  • Before the BEP starts, your project proposal will be send to you.


  • BEP’s run only during the 2nd and 4th quartile of each academic year.
  • The BEP starts the first day of the quartile
  • You have to dedicate 280 hours to a BEP, which is ~30 hours per week.
  • Your report has to be submitted on Canvas on the last Friday (deadline 20:00) before the start of the examination weeks of that quartile.
  • Presentations will be scheduled during the examination weeks, and overlap with exams will be prevented.


  • Below you can find examples of past BEP projects, to give you a feeling of the type of project you can do.

If you still have questions related to the BEP, please address Jasper Foolen (, GemZ 4.102) 

Selected recent projects

Regional strain differences in tendon – the missing link that explains failure of the reconstructed ACL Student: Wietske Velthuis. D. Stefanoska, dr. ir. J. Foolen

The influence of shear stress on prevascularized bone tissue engineered constructs Student: Rachel Loop. J. Melke, dr. S. Hofmann-Boss, dr. ir. J. Foolen

The (co-)location of cadherin 11 and connexin 43 in an in vitro model of cultured murine tenocytes representative to the in vivo orientation of healthy and tendinopathic tenocytes Student: Eva Spaander. Ir. M. van Vijven, dr. ir. J. Foolen

The influence of gap junctions on the amount of remodelling in tendon-derived cells on an in-vitro tissue platform Student: Ilja Boone. Dr. ir. J. Foolen

Structural microscopic difference in shear deformation response in femoral condyle and trochlea of porcine articular cartilage Student: Carlijn Buck. R.R.H. van Loo, dr. ir. M. Nickien, dr. C.C. van Donkelaar

Degeneration of articular cartilage as a result of small shear deformation Student: Christian Jongen. R.R.H. van Loo, dr. ir. M. Nickien, dr. C.C. van Donkelaar

Strain avoidance of tendon-derived cells as a response to uniaxial cyclic strain Student: Esther Arends. ir. M. van Vijven and dr. ir. J. Foolen.

Hyperoxic in vitro culture conditions result in most osteoclasts for a possible treatment against osteopetrosis Student: Freek van der Heijden. S.J.A. Remmers, dr. S. Hofmann Boss, prof. dr. K. Ito

The influence of sliding direction on cartilage wear following sliding indentation against varying implant materials Student: Geraldine Vis. ir. A.H.A. Damen, dr. i.r M. Nickien, dr. C.C van Donkelaar

Compressive moduli and distributions of bioactive glass based grafts with various granule sizes Student: Jordy van Leeuwen. N.A.P. van Gestel, K. Ito, dr. S. Hofmann-Boss

The involvement of microtubules in the presence and localization of cellular junctions in primary tendon cells Student: Joyce Kimenai. ir. M. van Vijven, dr. ir. J. Foolen

The mineralization of porous silk fibroin scaffolds: Cellular or non-cellular processes Student: Koen van Putten. J. Melke, S. Hofmann

The potential of mesenchymal stem cells in nucleus pulposus matrix hydrogels for intervertebral disc regeneration Students: Daan Janssen / Lieke van Dommelen / Iris Lauwers. dr. ir. V. Mouser, prof. dr. K. Ito

Differences of morphological parameters between the two sides of a worn tibial plateau examined by micro-computed tomography Student: Sanne Eemers. dr. ir. B. van Rietbergen