Bachelor end projects

Course Description
The Bachelor End Project (BEP) is an introduction into performing an individual research project. You will learn how to formulate a research question with the corresponding hypothesis and to design the right experiments or simulations to answer your research question. Different practical and analytical skills will be developed and improved, depending on the topic of the project. Finally, you will learn how to summarize the obtained insights in a scientific report and presentation.

Applying and Selection

  • To apply for a BEP, subscribe to 8Z4000 on Osiris and chose your 3 favorite groups.
  • The ‘onderwijsbureau’ will then check eligibility and send you an application form.
  • Depending on availability, you will be assigned to our group.
  • We will then ask you to choose 3 subgroups and try to assign everyone to their first pick:
    • Bone biomechanics (biomechanics, numerical and/or experimental), Bert van Rietbergen
    • Bone tissue engineering (experimental), Sandra Hofmann
    • Articular Cartilage (numerical and/or experimental, Rene van Donkelaar
    • Intervertebral Disc (experimental), Keita Ito
    • Tendon & Ligaments (experimental), Jasper Foolen
  • You then sign the form and bring it to the coordinator (Jasper Foolen, GemZ 4.102)
  • Before the BEP starts, your project proposal will be send to you.


  • BEP’s run only during the 2nd and 4th quartile of each academic year.
  • The BEP starts the first day of the quartile
  • You have to dedicate 280 hours to a BEP, which is ~30 hours per week.
  • Your report has to be submitted on Canvas on the last Friday (deadline 20:00) before the start of the examination weeks of that quartile.
  • Presentations will be scheduled during the examination weeks, and overlap with exams will be prevented.


  • Below, you can find an overview of past BEP projects, to give you a feeling of the type of project you can do.

If you still have questions related to the BEP, please address Jasper Foolen (, GemZ 4.102) 

Recent projects

Structural microscopic difference in shear deformation response in femoral condyle and trochlea of porcine articular cartilage Student: Carlijn Buck. R.R.H. van Loo, dr. ir. M. Nickien, dr. C.C. van Donkelaar

Degeneration of articular cartilage as a result of small shear deformation Student: Christian Jongen. R.R.H. van Loo, dr. ir. M. Nickien, dr. C.C. van Donkelaar

Strain avoidance of tendon-derived cells as a response to uniaxial cyclic strain Student: Esther Arends. ir. Marc van Vijven and dr. ir. Jasper Foolen.

Hyperoxic in vitro culture conditions result in most osteoclasts for a possible treatment against osteopetrosis Student: Freek van der Heijden. S.J.A. Remmers, dr. S. Hofmann Boss, prof. dr. K. Ito

The influence of sliding direction on cartilage wear following sliding indentation against varying implant materials Student: Geraldine Vis. ir. A.H.A. Damen, dr. i.r M. Nickien and dr. C.C van Donkelaar

Compressive moduli and distributions of bioactive glass based grafts with various granule sizes Student: Jordy van Leeuwen. N.A.P. van Gestel, K. Ito, S. Hofmann-Boss

The involvement of microtubules in the presence and localization of cellular junctions in primary tendon cells Student: Joyce Kimenai. ir. Marc van Vijven and dr. ir. Jasper Foolen

The mineralization of porous silk fibroin scaffolds: Cellular or non-cellular processes Student: Koen van Putten. J. Melke, S. Hofmann

The potential of mesenchymal stem cells in nucleus pulposus matrix hydrogels for intervertebral disc regeneration Students: Daan Janssen / Lieke van Dommelen / Iris Lauwers. dr. ir. V. Mouser, prof. dr. K. Ito

Differences of morphological parameters between the two sides of a worn tibial plateau examined by micro-computed tomography Student: Sanne Eemers. dr. ir. B. van Rietbergen

Selected projects

Analysis of the movement of bioactive glass materials under compressive loadingIr. Nicole van Gestel, Dr. Sandra Hofmann, Bert van Rietbergen, Prof.dr. Keita Ito

DNA extraction from tissue engineered boneDr. Sandra Hofmann, Prof.dr. Keita Ito, Johanna Melke

Exploring thresholds for tissue swelling in articular cartilage, Dr. René van Donkelaar, Mieke Nickien

Influence of phenol red on osteogenic differentiation of human mesenchymal stem cells in 3DDr. Sandra Hofmann, Prof.dr. Keita Ito, Johanna Melke

Notochordal cell-rich nucleus pulposus matrix for chondrogenic differentiation of human mesenchymal stem cells, Stefan de Vries, Prof.dr. Keita Ito

Validation of μFEM for the development of an animal bone model to simulate human distal radius fractures, A.J. Arias Moreno, B. v. Rietbergen. Student: R.M. Nouwens.

Inducing damage in cartilage explants by repetitive loading, L. Henao Murillo, R. van Donkelaar. Student: T. Kleuskens.

Correlation between the biochemical composition of articular cartilage zones and mechanical failure, A. Heuijerjans, R. van Donkelaar. Student: J.W.T. Baart.

Evaluation of different cell seeding techniques for tissue engineered bone-like constructs, J. Melke, S. Hofmann, K. Ito. Student: M. Tuerlings.

The influence of BMP-2 on bone tissue engineered constructs, J. Melke, S. Hofmann, K. Ito. Student: E. Mallens.

Delamination of cartilage and bone, finished, C. van der Putten, R. v. Donkelaar

The in vitro environment of nucleus pulposus cells
finished, J. Brouns, C. Jacobs, J. Simons, E. Verhoijsen, B. v. Dijk, K. Ito 

Loading of chondrocytes in agarose, finished, J. Grolleman, L. Stemkens, B. v. Dijk, R. v. Donkelaar

Tissue engineering of bone-like tissue, finished, E. Munnig Schmidt, R. Schuiringa, J. Melke, S. Hofmann

Isolation and characterization of monocytes in vitrofinished, M. Sleddens, A. Vrehen, S. Remmers, S. Hofmann

Experimental intervertebral disc degeneration with chondroitinasefinished, L. Braun, S. d. Vries, B. v. Dijk, K. Ito

Adaption of density changes during modeling and remodeling in a human distal radius, finished, A.M. Voermans, M. Colloca, B. v. Rietbergen

Proteoglycan loss over time in mechanically damaged cartilage, finished, M. van Vijven, R. v. Donkelaar

Enhanced proteoglycan loss after collagen damage in cartilage explants, finished, R. de Rooij, R. v. Donkelaar

Tissue deformation based on cell density in histology, finished, J. Kok, R. van Donkelaar

µCT imaging of hydroxyapatite/silk fibroin scaffolds in a physiological environment, finished, J. Nooten, S. Hofmann

Analysis of cell-seeded silk fibroin scaffolds with fluorescence microscopy, finished, M. Kleuskens, K. Ito

Modification of silk fibroin scaffolds for μCT imaging in a physiological environment, finished, R. de Vries, K. Ito

Modification of silk fibroin scaffolds for x-ray opacity, finished, B. Snijders, S. Hofmann

DMTA of short-term culture chondrocyte-agarose constructs related to the PCM, finished, E. v Haaften, R. v. Donkelaar

Fourier transform infrafred spectroscopy comparison of healthy cartilage with cartilage with induced degradation, finished, F. Nieuwboer, R. v. Donkelaar

Estimating bone loading history from bone, finished, R. v.d. Meer, B. v. Rietbergen

Analytical modeling of the trabecular bone structure, finished, R. v.d. Brand, B. v. Rietbergen

Defining the cutting accuracy of autogenous bone grafts with use of surgical guides, finished, D.J. Wu, B. v. Rietbergen

Biomechanical analysis of a new assistance device for bedridden patients, finished, B. Horn, B. van Rietbergen