Patient specific prognosis of the risk of fracture in trabecular bone

Javad Hazrati Marangalou, PhD

Recent and ongoing developments in micro- and meso-scale imaging, testing and computational modelling of bone tissue have facilitated the first studies which combine bone architecture and composition to develop new criterion for the mechanical response and failure. This part of VPHOP project aims to develop and validate methods required to diagnose and to prognose patient specific elastic and strength properties of bone from clinical measurements. A method will be developed and validated to convert tissue-level properties into continuum-level constitutive equations. The main goal of this project is to develop the homogenization methods to derive cancellous bone continuum-level mechanical properties from tissue-level morphology and material properties.

Link to dissertation

Hazrati Marangalou, J. (2013). Patient specific prediction of bone failure using microstructure-enhanced continuum finite element models. Eindhoven: Technische Universiteit Eindhoven. ((Co-)promot.: prof.dr. K. Ito & dr.ir. B. van Rietbergen).

This project is funded by VPHOP